2,4,6-Tri-tert-butylbenzoic acid

Base Information

Chemical Name:2,4,6-Tri-tert-butylbenzoic acid
CAS No.:66415-27-8
Molecular Formula:C19H30O2
Molecular Weight:290.446
Hs Code.:2916399090

Synonyms:2,4,6-tri-tert-butylbenzoic acid;2,4,6-Tri-tert-butyl-benzoesaeure;Ar((t)Bu)COOH;Benzoic acid,2,4,6-tris(1,1-dimethylethyl);

Suppliers and Price of 2,4,6-Tri-tert-butylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 2,4,6-Tri-tert-butylbenzoic acid

Chemical Property:

Melting Point:275 °C
Boiling Point:329.4±41.0 °C(Predicted)
PKA:3.06±0.10(Predicted)
PSA：37.30000
Density:0.961±0.06 g/cm3(Predicted)
LogP:5.27730

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,4,6-Tri-tert-butylbenzoic acid

There total 9 articles about 2,4,6-Tri-tert-butylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-38-9,18923-20-1
carbon dioxide

: 3975-77-7
1-bromo-2,4,6-tri-tert-butylbenzene

: 66415-27-8
2,4,6-tri-tert-butylbenzoic acid

Guidance literature:: 1-bromo-2,4,6-tri-tert-butylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; hexane; for 0.166667h; Inert atmosphere;
DOI:10.1021/acs.joc.9b01720

Reference yield: 13.0%

: 20208-55-3
2,4,6-tri-tert-butylbenzoyl chloride

: 66415-27-8
2,4,6-tri-tert-butylbenzoic acid

: 19873-22-4
2,2',4,4',6,6'-hexa-tert-butylbenzil

: 1-(2,4-Di-tert-butyl-phenyl)-2-(2,4,6-tri-tert-butyl-phenyl)-ethane-1,2-dione

: 2-Hydroxy-1,2-bis-(2,4,6-tri-tert-butyl-phenyl)-ethanone

Guidance literature:: With iodine; magnesium; In diethyl ether; benzene; for 40h; Further byproducts given; Ambient temperature;

Reference yield:

: 1460-02-2
1,3,5-Tri-tert-butylbenzene

: 66415-27-8
2,4,6-tri-tert-butylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; silver nitrate; aqueous nitric acid; bromine

2: butyl lithium / anschliessend Behandeln mit CO₂

With n-butyllithium; bromine; nitric acid; silver nitrate; acetic acid;
DOI:10.1139/v55-219