METHYL 2-CYANO-2-PROPYLPENTANOATE

Base Information

• Chemical Name: METHYL 2-CYANO-2-PROPYLPENTANOATE
• CAS No.: 66546-92-7
• Molecular Formula: C10H17NO2
• Molecular Weight: 183.25
• Mol file: 66546-92-7.mol

Synonyms:2-Cyano-2-propyl-pentanoic acid methyl ester;

Chemical Property of METHYL 2-CYANO-2-PROPYLPENTANOATE

Chemical Property:

• Vapor Pressure: 0.0871mmHg at 25°C
• Refractive Index: 1.4294
• Boiling Point: 225.3oC at 760 mmHg
• Flash Point: 96.3oC
• PSA: 50.09000
• Density: 0.961g/cm3
• LogP: 2.26958
• Storage Temp.: 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

Methyl2-cyano-2-propylpentanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-CYANO-2-PROPYLPENTANOATE

There total 3 articles about METHYL 2-CYANO-2-PROPYLPENTANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

propyl bromide (106-94-5) + ethyl 2-cyanoacetate (105-56-6) → methyl 2-cyano-2-propylpentanoate (66546-92-7)

Guidance literature:

ethyl 2-cyanoacetate; With sodium methylate; In methanol; for 0.25h; Inert atmosphere;

propyl bromide; In methanol; Inert atmosphere;

DOI:10.1016/j.poly.2020.114572

Reference yield:

1-iodo-propane (107-08-4) + methyl 2-cyanoacetate (105-34-0) → methyl 2-cyano-2-propylpentanoate (66546-92-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene;

DOI:10.1246/cl.1977.871

Reference yield:

→ methyl 2-cyano-2-propylpentanoate (66546-92-7)

Guidance literature:

With sodium methylate; In methanol; for 0.0833333h;

In methanol; Reflux;

upstream raw materials:

1-iodo-propane

methyl 2-cyanoacetate

propyl bromide

ethyl 2-cyanoacetate

Downstream raw materials:

di-N-propyl acetonitrile

valproic acid

Refernces

• 1、 -. "THERAPEUTIC PEPTIDES". Paragraph 0101. . Retrieved 2013/03/26.