3-HEXENE-1 6-DIOLE

Base Information

• Chemical Name: 3-HEXENE-1 6-DIOLE
• CAS No.: 67077-43-4
• Molecular Formula: C6H12O2
• Molecular Weight: 116.16
• Mol file: 67077-43-4.mol

Synonyms:3-Hexene-1,6-diol;

Chemical Property of 3-HEXENE-1 6-DIOLE

Chemical Property:

• PSA: 40.46000
• LogP: 0.30740
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-Hexene-1,6-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Hexene-1,6-diol is a useful reagent to synthesize pochoxime, a potent?inhibitor?of?heat shock protein 90 (HSP90). It can also be used for photochemical cyclization of Diels-Alder adducts.

Technology Process of 3-HEXENE-1 6-DIOLE

There total 5 articles about 3-HEXENE-1 6-DIOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

homoalylic alcohol (627-27-0) → (E/Z)-2-buten-1-ol (6117-91-5,542-72-3) + hex-3-ene-1,6-diol (67077-43-4)

Guidance literature:

Grubbs catalyst first generation; In methanol; water; at 100 ℃;

DOI:10.1016/j.jorganchem.2006.09.022

Reference yield:

homoalylic alcohol (627-27-0) + N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide (1262405-42-4) → hex-3-ene-1,6-diol (67077-43-4) + N-(6-hydroxyhex-3-enyl)-N-(4-methoxyphenyl)acetamide

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,6-dichloro-1,4-benzoquinone; In dichloromethane; for 168h; Inert atmosphere; Reflux;

DOI:10.1039/c0ob00308e

Reference yield:

homoalylic alcohol (627-27-0) + N-(4-methoxyphenyl)-N-(1,1,1-trifluoropent-4-en-2-yl)acetamide (1190108-24-7) → hex-3-ene-1,6-diol (67077-43-4) + (Z)-N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-7-hydroxyhept-4-en-2-yl)acetamide (1331747-24-0) + (E)-N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-7-hydroxyhept-4-en-2-yl)acetamide (1262405-40-2)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,6-dichloro-1,4-benzoquinone; In dichloromethane; for 108h; optical yield given as %de; Inert atmosphere; Reflux;

DOI:10.1039/c0ob00308e

upstream raw materials:

homoalylic alcohol

N-(4-methoxyphenyl)-N-(1,1,1-trifluoropent-4-en-2-yl)acetamide

N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide

N-benzyl-N-(but-3-en-1-yl)acetamide

Downstream raw materials:

6-(benzyloxy)hex-3-en-1-ol

C₅₁H₇₃ClN₂O₉Si₂

C₄₄H₆₁ClO₈Si₂

C₂₇H₃₇NO₃Si