N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide
• CAS No.: 1262405-42-4
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 1262405-42-4.mol

Synonyms:

Chemical Property of N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide

There total 2 articles about N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

but-3-enyl 4-methylbenzenesulfonate (778-29-0) + 4-methoxyacetanilide (51-66-1) → N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide (1262405-42-4)

Guidance literature:

4-methoxyacetanilide; With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In toluene; at 20 ℃; for 1h; Inert atmosphere;

but-3-enyl 4-methylbenzenesulfonate; In toluene; at 80 ℃; for 21h; Inert atmosphere;

DOI:10.1039/c0ob00308e

Reference yield:

4-methoxy-aniline (104-94-9) → N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide (1262405-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / 0.67 h / 0 - 20 °C / Inert atmosphere

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / toluene / 1 h / 20 °C / Inert atmosphere

2.2: 21 h / 80 °C / Inert atmosphere

With pyridine; tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In toluene;

DOI:10.1039/c0ob00308e

Reference yield:

homoalylic alcohol (627-27-0) + N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide (1262405-42-4) + methyl iodide (74-88-4) → (E)-1,6-dimethoxyhex-3-ene + (Z)-1,6-dimethoxyhex-3-ene + N-(6-methoxyhex-3-enyl)-N-(4-methoxyphenyl)acetamide + N-(6-methoxyhex-3-enyl)-N-(4-methoxyphenyl)acetamide (1262405-39-9)

Guidance literature:

homoalylic alcohol; N-(but-3-enyl)-N-(4-methoxyphenyl)acetamide; With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,6-dichloro-1,4-benzoquinone; In dichloromethane; for 168h; Inert atmosphere; Reflux;

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 23h; optical yield given as %de; Inert atmosphere;

DOI:10.1039/c0ob00308e

upstream raw materials:

but-3-enyl 4-methylbenzenesulfonate

4-methoxyacetanilide

4-methoxy-aniline

Downstream raw materials:

hex-3-ene-1,6-diol

N-(6-methoxyhex-3-enyl)-N-(4-methoxyphenyl)acetamide