5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-

Base Information

• Chemical Name: 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-
• CAS No.: 67122-26-3
• Molecular Formula: C20H16O5
• Molecular Weight: 336.344

Synonyms:4-demethoxy-7,9-bisdeoxydaunomycinone;(+/-)-4-demethoxy-7,9-dideoxydaunomycinone;4-demethoxy-7,9-dideoxy daunomycinone;9-acetyl-6,11-dihydroxy-7,8,9,10-tetrahydronaphthacen-5,12-dione;4-demethoxcy-7,9-didesoxydaunomycinone;8-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione;

Chemical Property of 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-

Chemical Property:

• PSA: 91.67000
• LogP: 2.56710

Purity/Quality:

95% ^*data from raw suppliers

8-Acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione is used as a reactant in the synthesis of idarubicinone-7-β-D-glucuronides via glucuronidation of idarubicinone with D-glucuronic acid as a key step.

Technology Process of 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-

There total 58 articles about 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,10-Dihydroxy-1,2-dihydro-cyclobuta[b]anthracene-4,9-dione (89023-98-3) + methyl vinyl ketone (78-94-4,25038-87-3) → (+/-)4-demethoxy-7,9-dideoxydaunomycinone (67122-26-3,77422-62-9)

Guidance literature:

In various solvent(s); at 200 ℃; for 5h;

DOI:10.1016/S0040-4039(00)94157-1

Reference yield: 90.0%

8-acetyl-7,8,9,10-tetrahydro-6,11-dimethoxy-5,12-naphthacenedione (77422-60-7) → 2-acetyl-1,2,3,4,6,11-hexahydro-5,12-dihydroxynaphthacene-6,11-quinone (67122-26-3)

Guidance literature:

With aluminium trichloride; In benzene; for 3h;

Reference yield: 87.0%

1-(5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1-ethanone (33654-68-1,110881-09-9) + Phthaloyl dichloride (88-95-9) → 2-acetyl-1,2,3,4,6,11-hexahydro-5,12-dihydroxynaphthacene-6,11-quinone (67122-26-3)

Guidance literature:

With aluminium trichloride; In nitrobenzene; at 100 ℃; for 1h;

DOI:10.1081/SCC-120030758

upstream raw materials:

Glyoxal

leuco-2-(3'-oxo-n-butane)quinizarin

8-acetyl-7,8,9,10-tetrahydro-6,11-dimethoxy-5,12-naphthacenedione

9,10-Dihydroxy-2,3-dihydro-anthracene-1,4-dione

Downstream raw materials:

8-Acetyl-6,11-dihydroxy-naphthacene-5,12-dione

3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-naphthacenyl 2-(acetyloxy)-2-phenylethanoate

3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-naphthacenyl 2-(acetyloxy)-2-phenyl ethanoate

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