Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7 -dihydro-2-(hydroxymethyl)-4-oxo-

Base Information

Chemical Name:Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7 -dihydro-2-(hydroxymethyl)-4-oxo-
CAS No.:672326-03-3
Molecular Formula:C22H23ClN2O5S
Molecular Weight:462.954
Hs Code.:

Thieno[2,3-b]pyridine-5-carboxamide,
N-[(4-chlorophenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7
-dihydro-2-(hydroxymethyl)-4-oxo-

Synonyms:

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Chemical Property of Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7 -dihydro-2-(hydroxymethyl)-4-oxo-

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Technology Process of Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7 -dihydro-2-(hydroxymethyl)-4-oxo-

There total 1 articles about Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-7-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-4,7 -dihydro-2-(hydroxymethyl)-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 292144-08-2,863102-00-5
N-(4-chlorobenzyl)-4-hydroxy-2-(hydroxymethyl)thieno[2,3-b]pyridine-5-carboxamide

: 36236-76-7
4-(bromomethyl)-2,2-dimethyl-1,3-dioxolane

: 672326-03-3
N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-2-(hydroxymethyl)-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

Guidance literature:: With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 17h;

Reference yield:

: 672326-03-3
N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-2-(hydroxymethyl)-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

: 804511-32-8
N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-2-((((2R)-2-(2-furyl)-2-hydroxyethyl)(methyl)amino)methyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-trimethyl-pyridine; dmap; methanesulfonyl chloride / DMF (N,N-dimethyl-formamide) / 4 h / 20 °C

2: cesium carbonate / DMF (N,N-dimethyl-formamide) / 17 h / 60 °C / 3 ? molecular sieves

With 2,4,6-trimethyl-pyridine; dmap; cesium carbonate; methanesulfonyl chloride; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 672326-03-3
N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-2-(hydroxymethyl)-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

: 804511-26-0
2-(((2-(1-benzofuran-2-yl)-2-hydroxyethyl)(methyl)amino)methyl)-N-(4-chlorobenzyl)-7-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-trimethyl-pyridine; dmap; methanesulfonyl chloride / DMF (N,N-dimethyl-formamide) / 4 h / 20 °C

2: cesium carbonate / DMF (N,N-dimethyl-formamide) / 17 h / 60 °C / 3 ? molecular sieves

With 2,4,6-trimethyl-pyridine; dmap; cesium carbonate; methanesulfonyl chloride; In DMF (N,N-dimethyl-formamide);