6,7-Dimethoxyquinoline

Base Information

• Chemical Name: 6,7-Dimethoxyquinoline
• CAS No.: 67278-27-7
• Molecular Formula: C11H11NO2
• DSSTox Substance ID: DTXSID80446028
• Nikkaji Number: J1.381.026E
• Wikidata: Q82264591
• ChEMBL ID: CHEMBL66705
• Mol file: 67278-27-7.mol

Synonyms:6,7-dimethoxyquinoline;67278-27-7;6,7-Dimethoxy-quinoline;CHEMBL66705;Quinoline, 6,7-dimethoxy-;SCHEMBL4299023;DTXSID80446028;PCDPMVJGEGAJBI-UHFFFAOYSA-N;AMY35065;BDBM50039046;MFCD26668308;SB21494;AS-54369;CS-0050362;P17810;EN300-7442489;Z1813143006

Chemical Property of 6,7-Dimethoxyquinoline

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 189.078978594
• Heavy Atom Count: 14
• Complexity: 186

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C=CC=N2)OC

Technology Process of 6,7-Dimethoxyquinoline

There total 21 articles about 6,7-Dimethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6,7-dimethoxy-2-methylsulfanyl-quinoline → 6,7-Dimethoxy-chinolin (67278-27-7)

Guidance literature:

With nickel; In ethanol; Heating;

DOI:10.1055/s-2004-815400

Reference yield: 70.0%

6,6,7-trimethoxy-2,3,4,6-tetrahydroquinoline (106103-21-3) → 6,7-Dimethoxy-chinolin (67278-27-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 0.5h; Heating;

DOI:10.1021/jo00294a013

Reference yield: 25.0%

acrolein (107-02-8,25068-14-8) + 3,4-dimethoxyaniline (6315-89-5) → 6,7-Dimethoxy-chinolin (67278-27-7)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/j.jfluchem.2012.12.006

upstream raw materials:

1,2,3,4-tetrahydro-6,7-dimethoxyquinoline

6,7?dimethoxyquinoline?2?carboxylic acid

glycerol

3,4-dimethoxyaniline

Downstream raw materials:

1,2,3,4-tetrahydro-6,7-dimethoxyquinoline