3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE

Base Information

• Chemical Name: 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE
• CAS No.: 67592-40-9
• Molecular Formula: C14H9NO2
• Molecular Weight: 223.231
• Hs Code.: 2933399090
• Mol file: 67592-40-9.mol

Synonyms:3-Hydroxy-2-(pyridin-4-yl)inden-1-one;

Chemical Property of 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >300°C (dec.)
• Boiling Point: 442.527oC at 760 mmHg
• Flash Point: 221.433oC
• PSA: 50.19000
• Density: 1.407g/cm3
• LogP: 2.70420
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-2-(pyridin-4-yl)-1H-inden-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE

There total 4 articles about 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

pyridine-4-carbaldehyde (872-85-5) + 2-benzofuran-1(3H)-one (87-41-2) → 3-hydroxy-2-(pyridin-4-yl)-1H-inden-1-one (67592-40-9)

Guidance literature:

With sodium methylate; In methanol; at 65 ℃; for 2.5h;

DOI:10.1021/jm9909443

Reference yield: 52.0%

1H-indene-1,3(2H)-dione (606-23-5) + 4-iodopyridine (15854-87-2) → 3-hydroxy-2-(pyridin-4-yl)-1H-inden-1-one (67592-40-9)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); potassium tert-butylate; tert-butyl XPhos; In 1,4-dioxane; at 110 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.1c01149

Reference yield:

picoline (108-89-4) + phthalic anhydride (85-44-9) → 3-hydroxy-2-(pyridin-4-yl)-1H-inden-1-one (67592-40-9)

Guidance literature:

at 170 ℃; for 24h; Neat (no solvent);

upstream raw materials:

pyridine-4-carbaldehyde

2-benzofuran-1(3H)-one

picoline

phthalic anhydride

Downstream raw materials:

5-(pyridin-4-yl)methyl-2H-phthalazin-1-one

vatalanib