Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[8-[3-(1-methylethyl )phenyl]-1,4-dioxaspiro[4.5]dec-8-yl]amino]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[8-[3-(1-methylethyl )phenyl]-1,4-dioxaspiro[4.5]dec-8-yl]amino]propyl]-, 1,1-dimethylethyl ester
CAS No.:676135-14-1
Molecular Formula:C32H44F2N2O5
Molecular Weight:574.709
Hs Code.:

Carbamic acid,
[(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[8-[3-(1-methylethyl
)phenyl]-1,4-dioxaspiro[4.5]dec-8-yl]amino]propyl]-, 1,1-dimethylethyl
ester

Synonyms:

Suppliers and Price of Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[8-[3-(1-methylethyl )phenyl]-1,4-dioxaspiro[4.5]dec-8-yl]amino]propyl]-, 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[8-[3-(1-methylethyl )phenyl]-1,4-dioxaspiro[4.5]dec-8-yl]amino]propyl]-, 1,1-dimethylethyl ester

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Safty Information:

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Technology Process of Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[8-[3-(1-methylethyl )phenyl]-1,4-dioxaspiro[4.5]dec-8-yl]amino]propyl]-, 1,1-dimethylethyl ester

There total 2 articles about Carbamic acid, [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-[[8-[3-(1-methylethyl )phenyl]-1,4-dioxaspiro[4.5]dec-8-yl]amino]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 388071-27-0
tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate

: 676135-10-7
8-(3-isopropylphenyl)-1,4-dioxa-spiro[4.5]decane-8-amine acetate

: 676135-14-1
tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1,4-dioxa-spiro[4.5]decane-8-amino}propylcarbamate

Guidance literature:: With sodium hydroxide; In isopropyl alcohol; at 90 ℃; for 15.5h; Heating / reflux;

Reference yield: 52.0%

: 676135-14-1
tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1,4-dioxa-spiro[4.5]decane-8-amino}propylcarbamate

Guidance literature:

Reference yield: 62.0%

: 676135-14-1
tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1,4-dioxa-spiro[4.5]decane-8-amino}propylcarbamate

: 676135-15-2
N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1 ,4-dioxa-spiro[4.5]decane-8-amino}propyl)acetamide

Guidance literature:: tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1,4-dioxa-spiro[4.5]decane-8-amino}propylcarbamate; With trifluoroacetic acid; In dichloromethane;

In dichloromethane;

With sodium hydroxide; water; In dichloromethane;