Glycine, trifluoroacetate

Base Information

• Chemical Name: Glycine, trifluoroacetate
• CAS No.: 677-30-5
• Molecular Formula: C2H5NO2.C2HF3O2
• Molecular Weight: 189.091
• Mol file: 677-30-5.mol

Synonyms:

Chemical Property of Glycine, trifluoroacetate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, trifluoroacetate

There total 8 articles about Glycine, trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + trifluoroacetic acid (76-05-1) → glycinium trifluoroacetate (677-30-5) + phenylalaninium trifluoroacetate + (R)-2-Amino-3-phenyl-propionic acid; compound with trifluoro-acetic acid

Guidance literature:

With quaternary ammonium salt derived from cinchonidine; hydroxylamine hydrochloride; water; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; different amounts of reagent, other temperature for 1 step, 1.) CH₂Cl₂, -78 deg C, 7 h, 2.) THF, room temperature, 5 h, 3.) 4 h;

DOI:10.1016/S0040-4020(99)00211-2

Reference yield:

4-Methylbenzyl bromide (104-81-4) + trifluoroacetic acid (76-05-1) → glycinium trifluoroacetate (677-30-5) + 2-amino-3-p-tolyl-propionic acid; compound with trifluoro-acetic acid + 2-amino-3-p-tolyl-propionic acid; compound with trifluoro-acetic acid

Guidance literature:

With quaternary ammonium salt derived from cinchonidine; hydroxylamine hydrochloride; water; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) CH₂Cl₂, -78 deg C, 7 h, 2.) THF, room temperature, 5 h, 3.) 4 h;

DOI:10.1016/S0040-4020(99)00211-2

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) + trifluoroacetic acid (76-05-1) → glycinium trifluoroacetate (677-30-5) + (R)-2-Amino-3-(4-bromo-phenyl)-propionic acid; compound with trifluoro-acetic acid + (S)-2-Amino-3-(4-bromo-phenyl)-propionic acid; compound with trifluoro-acetic acid

Guidance literature:

With quaternary ammonium salt derived from cinchonidine; hydroxylamine hydrochloride; water; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) CH₂Cl₂, -78 deg C, 7 h, 2.) THF, room temperature, 5 h, 3.) 4 h;

DOI:10.1016/S0040-4020(99)00211-2

upstream raw materials:

benzyl bromide

trifluoroacetic acid

4-Methylbenzyl bromide

1-bromomethyl-4-bromobenzene

Downstream raw materials:

2,4,6-triiodo-5-[2-(2,2,2-trifluoroacetylamino)-acetylamino]-isophthalic acid dichloride

N-(phosphonemethyl)glycine

Refernces