1-Formylpyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: 1-Formylpyrrolidine-2-carboxylic acid
• CAS No.: 67985-73-3
• Molecular Formula: C6H9NO3
• Molecular Weight: 143.14100
• European Community (EC) Number: 835-638-6
• NSC Number: 227292,74450
• Nikkaji Number: J3.202.086K
• Mol file: 67985-73-3.mol

Synonyms:1-formylpyrrolidine-2-carboxylic acid;67985-73-3;Proline, 1-formyl- (9CI);N-Formyl-L-proline;prolal;NSC74450;SCHEMBL555101;1-formylpyrrolidine-2-carboxylicacid;EINECS 236-165-2;NSC 74450;NSC-74450;NSC227292;NSC 227292;NSC-227292;EN300-245806

Chemical Property of 1-Formylpyrrolidine-2-carboxylic acid

Chemical Property:

• PSA: 57.61000
• LogP: 0.26560
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 143.058243149
• Heavy Atom Count: 10
• Complexity: 157

Purity/Quality:

97% ^*data from raw suppliers

1-FORMYLPYRROLIDINE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(N(C1)C=O)C(=O)O

Technology Process of 1-Formylpyrrolidine-2-carboxylic acid

There total 3 articles about 1-Formylpyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formic acid (64-18-6) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 1-formylpyrrolidine-2-carboxylic acid (67985-73-3)

Guidance literature:

With acetic anhydride; at 0 ℃; for 1h;

DOI:10.1016/j.tetlet.2019.150989

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 1-formylpyrrolidine-2-carboxylic acid (67985-73-3)

Guidance literature:

With zinc(II) phthalocyanine; carbon dioxide; phenylsilane; at 25 ℃; for 6h; under 3750.38 Torr; chemoselective reaction; Autoclave;

DOI:10.1016/S1872-2067(17)62877-8

Reference yield:

2-(Benzoimidazole-1-carbonyl)-pyrrolidine-1-carbaldehyde (93033-07-9) → 1-formylpyrrolidine-2-carboxylic acid (67985-73-3)

Guidance literature:

In tetrahydrofuran; water; at 22 ℃; Kinetics;

upstream raw materials:

2-(Benzoimidazole-1-carbonyl)-pyrrolidine-1-carbaldehyde

formic acid

rac-Pro-OH

N,N-dimethyl-formamide

Downstream raw materials:

dimethyl 2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

methyl 6,7-dihydro-5H-pyrrolizine-1-carboxylate