2-Hydroxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Base Information

Chemical Name:2-Hydroxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate
CAS No.:82219-47-4
Molecular Formula:C20H24N2O7
Molecular Weight:404.41
Hs Code.:
UNII:KCZ95H3Y3U
Mol file:82219-47-4.mol

Synonyms:Nimodipine (m4);KCZ95H3Y3U;82219-47-4;UNII-KCZ95H3Y3U;2-hydroxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-hydroxyethyl) 5-(1-methylethyl) ester;3-(2-Hydroxyethyl) 5-isopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3-O-(2-hydroxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;SCHEMBL10748541;RNXRFRBWBFBZCQ-UHFFFAOYSA-N

Suppliers and Price of 2-Hydroxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Hydroxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Chemical Property:

PSA：130.68000
LogP:3.16870
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:404.15835111
Heavy Atom Count:29
Complexity:721

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCO

Technology Process of 2-Hydroxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

There total 4 articles about 2-Hydroxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 75130-56-2
2-acetoxyethyl isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

: 82219-47-4
(+/-)-O-Demethyl-Nimodipine

Guidance literature:: With sodium hydroxide; In 1,2-dimethoxyethane; water; for 3h; Ambient temperature;

Reference yield:

: 542-08-5
isopropyl acetoacetate

: 82219-47-4
(+/-)-O-Demethyl-Nimodipine

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / NH₃ (gas.) / 10 °C

2: 47 percent / ethanol / 12 h / Heating

3: 82 percent / dimethylformamide / 20 h / Heating

4: 60 percent / NaOH / H₂O; 1,2-dimethoxy-ethane / 3 h / Ambient temperature

With sodium hydroxide; ammonia; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 40100-28-5
isopropyl 3-aminocrotonate

: 82219-47-4
(+/-)-O-Demethyl-Nimodipine

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / ethanol / 12 h / Heating

2: 82 percent / dimethylformamide / 20 h / Heating

3: 60 percent / NaOH / H₂O; 1,2-dimethoxy-ethane / 3 h / Ambient temperature

With sodium hydroxide; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;