Nimodipine (m3)

Base Information

Chemical Name:Nimodipine (m3)
CAS No.:82219-48-5
Molecular Formula:C20H22N2O7
Molecular Weight:402.404
Hs Code.:
UNII:96S4GG1UPR
Nikkaji Number:J363.767K

Synonyms:Nimodipine (m3);UNII-96S4GG1UPR;96S4GG1UPR;82219-48-5;3-(2-Hydroxyethyl) 5-isopropyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-hydroxyethyl) 5-(1-methylethyl) ester;BAY-o-1762;SCHEMBL10744530;PWPBMCUBOQNEJD-UHFFFAOYSA-N;2-Hydroxyethyl isopropyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate;5-O-(2-hydroxyethyl) 3-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Suppliers and Price of Nimodipine (m3)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Nimodipine (m3)

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:402.14270105
Heavy Atom Count:29
Complexity:592

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=C(C(=N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCO

Technology Process of Nimodipine (m3)

There total 5 articles about Nimodipine (m3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 82219-47-4
(+/-)-O-Demethyl-Nimodipine

: 82219-48-5
O-Demethyl-Nimodipine Oxidized

Guidance literature:: With nitric acid; In water; for 1h; Heating;

Reference yield:

: 542-08-5
isopropyl acetoacetate

: 82219-48-5
O-Demethyl-Nimodipine Oxidized

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / NH₃ (gas.) / 10 °C

2: 47 percent / ethanol / 12 h / Heating

3: 82 percent / dimethylformamide / 20 h / Heating

4: 60 percent / NaOH / H₂O; 1,2-dimethoxy-ethane / 3 h / Ambient temperature

5: 66 percent / conc. HNO₃ / H₂O / 1 h / Heating

With sodium hydroxide; ammonia; nitric acid; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 40100-28-5
isopropyl 3-aminocrotonate

: 82219-48-5
O-Demethyl-Nimodipine Oxidized

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / ethanol / 12 h / Heating

2: 82 percent / dimethylformamide / 20 h / Heating

3: 60 percent / NaOH / H₂O; 1,2-dimethoxy-ethane / 3 h / Ambient temperature

4: 66 percent / conc. HNO₃ / H₂O / 1 h / Heating

With sodium hydroxide; nitric acid; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;