75130-56-2

Upstream product

• 127-09-3 sodium acetate 
• 54851-30-8 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-chloroethyl ester 5-isopropyl ester 
• 542-08-5 isopropyl acetoacetate 
• 40100-28-5 isopropyl 3-aminocrotonate 

Downstream Products

• 82219-47-4 (+/-)-O-Demethyl-Nimodipine 
• 82219-48-5 O-Demethyl-Nimodipine Oxidized 

Relevant academic research and scientific papers

Nimodipine: Synthesis and metabolic pathway

Key step of the synthesis of the calcium antagonistic cerebral vasodilator (±) isopropyl-2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (Bay e 9736, nimodipine) is the cyclising Michael addition. A pharmacokinetic study with 14C-nimodipine in the rat revealed as major metabolites the dihydropyridines as well as the pyridines. A potential metabolic pathway is discussed involving ether cleavage and oxidation to the pyridine form as primary biotransformation steps. Reference metabolites were synthesized using 1,4-dihydropyridines with appropriate functionalities as precursors.