(2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

Base Information

Chemical Name:(2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone
CAS No.:680610-53-1
Molecular Formula:C15H10F4O2
Molecular Weight:298.23200
Hs Code.:
DSSTox Substance ID:DTXSID70459586
Wikidata:Q82283392

Synonyms:680610-53-1;(2-fluoro-3-(trifluoromethyl)phenyl)(4-methoxyphenyl)methanone;(2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone;Methanone, [2-fluoro-3-(trifluoromethyl)phenyl](4-methoxyphenyl)-;[2-fluoro-3-(trifluoromethyl)phenyl](4-methoxyphenyl)methanone;SCHEMBL1407322;DTXSID70459586;[2-fluoro-3-(trifluoromethyl)phenyl]-(4-methoxyphenyl)methanone;AKOS018598039;(2-Fluoro-3-trifluoromethylphenyl)-(4-methoxyphenyl)-methanone;(2-fluoro-3-trifluoromethyl-phenyl)-(4-methoxyphenyl)-methanone;(2-fluoro-3-trifluoromethylphenyl)-(4-methoxy-phenyl)-methanone

Suppliers and Price of (2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

Chemical Property:

Boiling Point:389.6±42.0 °C(Predicted)
PSA：26.30000
Density:1.300±0.06 g/cm3(Predicted)
LogP:4.08410
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:298.06169221
Heavy Atom Count:21
Complexity:361

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)C2=C(C(=CC=C2)C(F)(F)F)F

Technology Process of (2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

There total 1 articles about (2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 680610-54-2
2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide

: 680610-53-1
(2-fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

Guidance literature:: DOI:10.1021/jm049194+

Reference yield:

: 680610-53-1
(2-fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

: 680611-14-7
3-(4-methoxy-phenyl)-7-trifluoromethyl-1H-indazole

Guidance literature:: With pyridine; dmap; hydrazine hydrate; at 100 ℃;
DOI:10.1021/jm049194+

Reference yield:

: 680610-53-1
(2-fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

: 4-(2-isopropyl-7-trifluoromethyl-2H-indazol-3-yl)-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NH₂NH₂*H₂O; DMAP; pyridine / 100 °C

2.1: NaH / dimethylformamide

2.2: dimethylformamide / 60 °C

2.3: BBr₃ / CH₂Cl₂; cyclohexane / 5 h / 20 °C

With pyridine; dmap; sodium hydride; hydrazine hydrate; In N,N-dimethyl-formamide;
DOI:10.1021/jm049194+