1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine

Base Information

Chemical Name:1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine
CAS No.:130549-78-9
Molecular Formula:C₂₅H₃₀FNO₃
Molecular Weight:411.517
Hs Code.:
Mol file:130549-78-9.mol

Synonyms:1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine

Suppliers and Price of 1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine

Chemical Property:

Vapor Pressure:3.71E-11mmHg at 25°C
Boiling Point:526°C at 760 mmHg
Flash Point:271.9°C
PSA：46.61000
Density:1.15g/cm³
LogP:4.91700

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine

There total 6 articles about 1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 123-62-6
propionic acid anhydride

: 109765-70-0
(+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol

: 109765-73-3,130549-78-9
(+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine

Guidance literature:: With pyridine; for 2h; Heating;
DOI:10.1021/jm00393a037

Reference yield: 49.0%

: 123-62-6
propionic acid anhydride

: 109765-71-1
(+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol

: 109765-74-4,130549-78-9
(+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine

Guidance literature:: With pyridine; for 2h; Heating;
DOI:10.1021/jm00393a037

Reference yield:

: 109765-67-5
(+/-)-(β)-1-benzyl-3-methyl-4-phenyl-4-piperidinol hydrochloride

: 109765-74-4,130549-78-9
(+/-)-(β)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol; H₂O / 24 h / 50 - 60 °C / 1520 Torr

2: KI, Na₂CO₃ / toluene / 48 h / Heating

3: 49 percent / pyridine / 2 h / Heating

With pyridine; hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; water; toluene;
DOI:10.1021/jm00393a037