N-phenylthiophene-2-carboxamide

Base Information

• Chemical Name: N-phenylthiophene-2-carboxamide
• CAS No.: 6846-13-5
• Molecular Formula: C11H9NOS
• Molecular Weight: 203.265
• DSSTox Substance ID: DTXSID30354189
• Nikkaji Number: J1.154.527K
• Wikidata: Q82132195
• ChEMBL ID: CHEMBL2046761
• Mol file: 6846-13-5.mol

Synonyms:N-phenylthiophene-2-carboxamide;6846-13-5;N-phenyl-2-thiophenecarboxamide;thiophenecarboxanilide;Thiophene-2-carboxylic acid phenylamide;SCHEMBL1929165;CHEMBL2046761;N-phenyl-thiophene-2-carboxamide;DTXSID30354189;SPA05-005;STK390964;AKOS000428147;NCGC00229668-01;Thiophene-2-carboxylic Acid Phenyl Amide;EU-0067481;AH-034/04930007;SR-01000394285;SR-01000394285-1;Z27782767

Chemical Property of N-phenylthiophene-2-carboxamide

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 203.04048508
• Heavy Atom Count: 14
• Complexity: 202

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)C2=CC=CS2

Technology Process of N-phenylthiophene-2-carboxamide

There total 46 articles about N-phenylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-thiophenylcarboxylic acid (527-72-0) + aniline (62-53-3) → N-phenyl-2-thiophenecarboxamide (6846-13-5)

Guidance literature:

With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1039/c9ob00699k

Reference yield: 95.0%

2-Iodothiophene (3437-95-4,149762-92-5) + aniline (62-53-3) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → N-phenyl-2-thiophenecarboxamide (6846-13-5)

Guidance literature:

In N,N-dimethyl-formamide; at 25 ℃; for 48h; Irradiation; Green chemistry;

DOI:10.1039/d0cy01717e

Reference yield: 93.0%

2-Iodothiophene (3437-95-4,149762-92-5) + carbon monoxide (201230-82-2) + aniline (62-53-3) → N-phenyl-2-thiophenecarboxamide (6846-13-5)

Guidance literature:

With potassium phosphate; Pd((imidazolium)acetonaphthene)(allyl)Cl; In toluene; at 90 ℃; for 19h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/ol401550h

upstream raw materials:

thiophene

phenyl isocyanate

2-Thiophenecarbonyl chloride

aniline

Downstream raw materials:

N-phenylthiophene-2-carbonimidoyl chloride

4-[(thiophene-2-carbonyl)-amino]-benzenesulfonyl chloride

2,4-diphenylthiophene

3-phenylthiophene