4-Chloro-2-(4-methoxyphenyl)pyrimidine

Base Information

Chemical Name:4-Chloro-2-(4-methoxyphenyl)pyrimidine
CAS No.:68535-54-6
Molecular Formula:C11H9ClN2O
Molecular Weight:220.65500
Hs Code.:
DSSTox Substance ID:DTXSID20394433
Wikidata:Q82193817
Mol file:68535-54-6.mol

Synonyms:4-chloro-2-(4-methoxyphenyl)pyrimidine;68535-54-6;DTXSID20394433;AKOS009845606;SB59587;2-(p-methoxyphenyl)-4-chloropyrimidine;CS-0242679;EN300-253801;SR-01000495746;SR-01000495746-1;Z445153156

Suppliers and Price of 4-Chloro-2-(4-methoxyphenyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-chloro-2-(4-methoxyphenyl)pyrimidine
10mg
$ 45.00

AK Scientific
4-Chloro-2-(4-methoxyphenyl)pyrimidine
1g
$ 623.00

Total 4 raw suppliers

Chemical Property of 4-Chloro-2-(4-methoxyphenyl)pyrimidine

Chemical Property:

PSA：35.01000
LogP:2.80560
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:220.0403406
Heavy Atom Count:15
Complexity:195

Purity/Quality:

97% ^*data from raw suppliers

4-chloro-2-(4-methoxyphenyl)pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NC=CC(=N2)Cl

Technology Process of 4-Chloro-2-(4-methoxyphenyl)pyrimidine

There total 3 articles about 4-Chloro-2-(4-methoxyphenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 88627-13-8
2-(p-methoxyphenyl)-4-hydroxypyrimidine

: 68535-54-6
2-(p-methoxyphenyl)-4-chloropyrimidine

Guidance literature:: With trichlorophosphate; for 4h; Heating;
DOI:10.1007/BF00505770

Reference yield: 82.0%

: 3934-20-1
2,6-Dichloropyrimidine

: 5720-07-0
4-methoxyphenylboronic acid

: 68535-54-6
2-(p-methoxyphenyl)-4-chloropyrimidine

: 75634-04-7
2-chloro-4-(p-methoxyphenyl)pyrimidine

Guidance literature:: With potassium fluoride; di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); In tetrahydrofuran; water; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ja209424z

Reference yield:

: 51721-68-7
4-methoxybenzamidine hydrochloride

: 68535-54-6
2-(p-methoxyphenyl)-4-chloropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / ethanol / 5 h / Heating

2: 85 percent / POCl₃ / 4 h / Heating

With trichlorophosphate; In ethanol;
DOI:10.1007/BF00505770