(R*,S*)-3,3'-(1,2-Ethanediyl)bis(2-(2-pyridinyl)-4-thiazolidinone)

Base Information

• Chemical Name: (R*,S*)-3,3'-(1,2-Ethanediyl)bis(2-(2-pyridinyl)-4-thiazolidinone)
• CAS No.: 131420-42-3
• Molecular Formula: C₁₈H₁₈N₄O₂S₂
• Molecular Weight: 386.499
• DSSTox Substance ID: DTXSID30927190
• Wikidata: Q76279280
• Mol file: 131420-42-3.mol

Synonyms:BRN 4239697;(R*,S*)-3,3'-(1,2-Ethanediyl)bis(2-(2-pyridinyl)-4-thiazolidinone);(R*,R*)-(+-)-3,3'-(1,2-Ethanediyl)bis(2-(3-pyridinyl)-4-thiazolidinone);4-Thiazolidinone, 3,3'-(1,2-ethanediyl)bis(2-(2-pyridinyl)-, (R*,S*)-;4-Thiazolidinone, 3,3'-(1,2-ethanediyl)bis(2-(3-pyridinyl)-, (R*,R*)-(+-)-;131420-41-2;131420-42-3;DTXSID30927190;C18H18N4O2S2;LS-151734;LS-151735;3,3'-(Ethane-1,2-diyl)bis[2-(pyridin-2-yl)-1,3-thiazolidin-4-one]

Chemical Property of (R*,S*)-3,3'-(1,2-Ethanediyl)bis(2-(2-pyridinyl)-4-thiazolidinone)

Chemical Property:

• Boiling Point: 722.7°Cat760mmHg
• Flash Point: 390.9°C
• Density: 1.38g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 386.08711818
• Heavy Atom Count: 26
• Complexity: 489

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(=O)N(C(S1)C2=CC=CC=N2)CCN3C(SCC3=O)C4=CC=CC=N4
• Isomeric SMILES: C1C(=O)N([C@H](S1)C2=CC=CC=N2)CCN3[C@H](SCC3=O)C4=CC=CC=N4

Technology Process of (R*,S*)-3,3'-(1,2-Ethanediyl)bis(2-(2-pyridinyl)-4-thiazolidinone)

There total 3 articles about (R*,S*)-3,3'-(1,2-Ethanediyl)bis(2-(2-pyridinyl)-4-thiazolidinone) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

pyridine-2-carbaldehyde (1121-60-4) + mercaptoacetic acid (68-11-1) + ethylenediamine (107-15-3,85404-18-8) → 3,3'-(ethane-1,2-diyl)bis(2-(pyridin-2-yl)thiazolidin-4-one) (882522-33-0,131420-42-3)

Guidance literature:

With nano-colloidal silica-tethered polyhedral oligomeric silsesquioxanes with eight branches of 3-aminopropyltriethoxysilane; In toluene; for 0.333333h; Sonication;

DOI:10.1515/znb-2017-0091

Reference yield: 40.0%

(1E,1’E)-N,N’-(ethane-1,2-diyl)bis(1-(pyridin-2-yl)methanimine) (2847-14-5) + mercaptoacetic acid (68-11-1) → 3,3'-(ethane-1,2-diyl)bis(2-(pyridin-2-yl)thiazolidin-4-one) (882522-33-0,131420-42-3)

Guidance literature:

In benzene; at 5 - 10 ℃; for 0.25h;

DOI:10.1002/jhet.5570430228

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → 3,3'-(ethane-1,2-diyl)bis(2-(pyridin-2-yl)thiazolidin-4-one) (882522-33-0,131420-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / ethanol / Heating

2: 40 percent / benzene / 0.25 h / 5 - 10 °C

In ethanol; benzene;

DOI:10.1002/jhet.5570430228

upstream raw materials:

pyridine-2-carbaldehyde

mercaptoacetic acid

ethylenediamine

(1E,1’E)-N,N’-(ethane-1,2-diyl)bis(1-(pyridin-2-yl)methanimine)

Downstream raw materials:

C₁₈H₁₈N₄O₆S₂