CAPROYL-MET-OH

Base Information

• Chemical Name: CAPROYL-MET-OH
• CAS No.: 68862-41-9
• Molecular Formula: C11H21NO3S
• Molecular Weight: 247.359
• Mol file: 68862-41-9.mol

Synonyms:L-Methionine,N-(1-oxohexyl);N-hexanoyl-L-Met;N-hexanoyl-L-methionine;

Chemical Property of CAPROYL-MET-OH

Chemical Property:

• PSA: 91.70000
• LogP: 2.28010
• Storage Temp.: -15°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Hexanamido-4-(methylthio)butanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CAPROYL-MET-OH

There total 4 articles about CAPROYL-MET-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-methionine (63-68-3,26062-47-5,58576-49-1) + hexanoic acid (142-62-1) → N-hexanoyl-L-methionine (68862-41-9)

Guidance literature:

With adenosine monophosphate ligase SfaB from Streptomyces thioluteus; ATP; magnesium chloride; Cleland's reagent; In aq. buffer; at 30 ℃; for 6h; pH=8; Enzymatic reaction;

DOI:10.1002/anie.202010042

Reference yield:

(S)-2-Hexanoylamino-4-methylsulfanyl-butyric acid methyl ester (500145-29-9) → N-hexanoyl-L-methionine (68862-41-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(02)02178-0

Reference yield:

Hexanoyl chloride (142-61-0) → N-hexanoyl-L-methionine (68862-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / Et₃N / CH₂Cl₂

2: aq. LiOH / tetrahydrofuran

With lithium hydroxide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(02)02178-0

upstream raw materials:

(S)-2-Hexanoylamino-4-methylsulfanyl-butyric acid methyl ester

Hexanoyl chloride

L-methionine

hexanoic acid

Downstream raw materials:

L-methionine

2-[3-(2-{2-[(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-[4-(tert-butyl-diphenyl-silanyloxy)-phenyl]-propionylamino}-3-methyl-butyryloxy)-2-(2-hexanoylamino-4-methylsulfanyl-butyrylamino)-butyrylamino]-but-2-enoic acid allyl ester

Refernces

• 1、 Koreishi, Mayuko,Nakatani, Yasuyuki,Ooi, Manami,Imanaka, Hiroyuki,Imamura, Koreyoshi,Nakanishi, Kazuhiro. "Purification, characterization, molecular cloning, and expression of a new aminoacylase from streptomyces mobaraensis that can hydrolyze N-(Middle/Long)-chain-fatty-acyl-L-amino acids as well as N-Short-chain-acyl-L- amino acids". experimental part. p. 1940 - 1947. Retrieved 2010/07/02.