2-(Methylamino)quinolin-8-ol

Base Information

• Chemical Name: 2-(Methylamino)quinolin-8-ol
• CAS No.: 70125-17-6
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.19900
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID30362502
• Wikidata: Q82145636
• Mol file: 70125-17-6.mol

Synonyms:2-(methylamino)quinolin-8-ol;70125-17-6;2-(METHYLAMINO)-8-QUINOLINOL;CHEMBRDG-BB 5175081;Oprea1_836237;SCHEMBL1041892;8-hydroxy-2-methylaminoquinoline;DTXSID30362502;HMS1579M16;8-Hydroxy-2-(methylamino)quinoline;MFCD00168932;AKOS006282521;SB68187;BS-38396;CS-0455055;FT-0730099

Chemical Property of 2-(Methylamino)quinolin-8-ol

Chemical Property:

• Vapor Pressure: 3.8E-06mmHg at 25°C
• Boiling Point: 374.7oC at 760 mmHg
• PKA: 5.72±0.30(Predicted)
• Flash Point: 180.4oC
• PSA: 45.15000
• Density: 1.293g/cm3
• LogP: 2.05510
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

98% ^*data from raw suppliers

2-(methylamino)-8-quinolinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC2=C(C=CC=C2O)C=C1

Technology Process of 2-(Methylamino)quinolin-8-ol

There total 6 articles about 2-(Methylamino)quinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-chloroquinolin-8-ol (31568-91-9) + methylamine (74-89-5) → 2-(methylamino)quinolin-8-ol (70125-17-6)

Guidance literature:

In tetrahydrofuran; 1,4-dioxane; at 200 ℃; for 0.2h; microwave irradiation;

DOI:10.1021/jm070190p

Reference yield: 52.0%

2-(benzyl(methyl)amino)quinolin-8-ol → 2-(methylamino)quinolin-8-ol (70125-17-6)

Guidance literature:

With palladium on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; regiospecific reaction;

DOI:10.1039/c8ob00911b

Reference yield:

H2NMe + 2-chloroquinolin-8-ol (31568-91-9) → 2-(methylamino)quinolin-8-ol (70125-17-6)

Guidance literature:

With ammonium hydroxide; In CH₂Cl₂/MeOH; ethanol;

upstream raw materials:

2-chloroquinolin-8-ol

methylamine

2--bromo--8--methoxyquinoline