1-(Benzoyloxy)-2,2,6,6-tetramethylpiperidine

Base Information

• Chemical Name: 1-(Benzoyloxy)-2,2,6,6-tetramethylpiperidine
• CAS No.: 7031-95-0
• Molecular Formula: C16H23NO2
• Molecular Weight: 261.364
• DSSTox Substance ID: DTXSID10561814
• Nikkaji Number: J619.949F
• Mol file: 7031-95-0.mol

Synonyms:2,2,6,6-Tetramethylpiperidin-1-yl benzoate;1-(Benzoyloxy)-2,2,6,6-tetramethylpiperidine;7031-95-0;SCHEMBL4625144;DTXSID10561814

Chemical Property of 1-(Benzoyloxy)-2,2,6,6-tetramethylpiperidine

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 261.172878976
• Heavy Atom Count: 19
• Complexity: 314

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(CCCC(N1OC(=O)C2=CC=CC=C2)(C)C)C

Technology Process of 1-(Benzoyloxy)-2,2,6,6-tetramethylpiperidine

There total 68 articles about 1-(Benzoyloxy)-2,2,6,6-tetramethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + Tellurobenzoic acid Te-(4-fluoro-phenyl) ester (143565-02-0) → 1-benzoxy-2,2,6,6-tetramethylpiperidine (7031-95-0)

Guidance literature:

In benzene; at 80 ℃; for 5h;

DOI:10.1021/ja00047a066

Reference yield: 95.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + benzaldehyde (100-52-7) → 2,2,6,6-tetramethylpiperidin-1-ol (7031-93-8) + 1-benzoxy-2,2,6,6-tetramethylpiperidine (7031-95-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-dimethyl-1,2,4-triazolium iodide; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/anie.200802735

Reference yield: 95.0%

2,2,6,6-tetramethyl-piperidine-N-oxyl (2564-83-2) + benzaldehyde (100-52-7) → 1-benzoxy-2,2,6,6-tetramethylpiperidine (7031-95-0)

Guidance literature:

With styrene; tert.-butylhydroperoxide; iron(II) chloride; In decane; acetonitrile; at 85 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja204226n

upstream raw materials:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

benzoyl radical

Tellurobenzoic acid Te-(4-fluoro-phenyl) ester

TEMPOH*HCl

Downstream raw materials:

2,2,6,6-tetramethyl-1-(o-tolyl)piperidine

2,2,6,6-tetramethyl-1-(4-nitrophenyl)piperidine

2,2,6,6-tetramethyl-1-(4-phenylbutyl)piperidine