3,6-Dimethylterephthalaldehyde

Base Information

• Chemical Name: 3,6-Dimethylterephthalaldehyde
• CAS No.: 7044-92-0
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol file: 7044-92-0.mol

Synonyms:2,5-dimethyl-terephthalaldehyde;1,4-diformyl-2,5-dimethylbenzene;3,6-Dimethylterephthalaldehyde;2.5-Dimethylterephthalaldehyd;2,5-dimethylterephthalaldehyde;2,5-Dimethylbenzene-1,4-dicarboxaldehyde;2,5-Dimethyl-terephthalaldehyd;2,5-Dimethyl-benzene-1,4-dicarbaldehyde;

Chemical Property of 3,6-Dimethylterephthalaldehyde

Chemical Property:

• Melting Point: 55-56 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 303.3±30.0 °C(Predicted)
• PSA: 34.14000
• Density: 1.116±0.06 g/cm3(Predicted)
• LogP: 1.92840
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

2,5-Dimethylbenzene-1,4-dicarbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-Dimethylterephthalaldehyde

There total 11 articles about 3,6-Dimethylterephthalaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,5-dibromo-p-xylene (1074-24-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,5-dimethyl-1,4-benzenedicarboxaldehyde (7044-92-0)

Guidance literature:

Multistep reaction.;

DOI:10.1039/b212102f

Reference yield: 83.4%

2,5-bis(chloromethyl)-p-xylene (6298-72-2) → 2,5-dimethyl-1,4-benzenedicarboxaldehyde (7044-92-0)

Guidance literature:

With hexamethylenetetramine; acetic acid; In water; at 110 ℃; for 1h;

DOI:10.1021/jacs.0c09684

Reference yield: 75.0%

2-nitropropane (79-46-9) + 2,5-dibromomethyl-p-xylene (35168-62-8) → 2,5-dimethyl-1,4-benzenedicarboxaldehyde (7044-92-0)

Guidance literature:

2-nitropropane; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

2,5-dibromomethyl-p-xylene; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.25h; Inert atmosphere;

DOI:10.1002/ejoc.201701325

upstream raw materials:

2,5-bis(chloromethyl)-p-xylene

2,5-dibromo-p-xylene

N,N-dimethyl-formamide

1,2,4,5-tetramethylbenzene

Downstream raw materials:

2,5-bis-bromomethyl-terephthalic acid diethyl ester

benzyl (2,5-dimethyl-1,4-phenylene)bis((diphenoxyphosphoryl)methylene)dicarbamate

Refernces

• 1、 Krishnaraj, Chidharth,Sekhar Jena, Himanshu,Bourda, Laurens,Laemont, Andreas,Pachfule, Pradip,Roeser, Jér?me,Chandran, C. Vinod,Borgmans, Sander,Rogge, Sven M.J.,Leus, Karen,Stevens, Christian V.,Martens, Johan A.,Van Speybroeck, Veronique,Breynaert, Eric,Thomas, Arne,Van Der Voort, Pascal. "Strongly Reducing (Diarylamino)benzene-Based Covalent Organic Framework for Metal-Free Visible Light Photocatalytic H2O2Generation". supporting information. p. 20107 - 20116. Retrieved 2020/11/27.
• 2、 Sun, Qi,Pan, Yanxiong,Wang, Xiaoliang,Li, Hui,Farmakes, Jasmin,Aguila, Briana,Yang, Zhongyu,Ma, Shengqian. "Mapping out the Degree of Freedom of Hosted Enzymes in Confined Spatial Environments". . p. 3184 - 3195. Retrieved 2019/12/11.