ETHYL 2-(BENZYLAMINO)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE HYDROCHLORIDE

Base Information

• Chemical Name: ETHYL 2-(BENZYLAMINO)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE HYDROCHLORIDE
• CAS No.: 15087-95-3
• Molecular Formula: C14H16 N2 O2 S
• Molecular Weight: 276.359
• Hs Code.: 2934100090
• Mol file: 15087-95-3.mol

Synonyms:5-Thiazolecarboxylicacid, 2-(benzylamino)-4-methyl-, ethyl ester (8CI)

Chemical Property of ETHYL 2-(BENZYLAMINO)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 3.53E-07mmHg at 25°C
• Boiling Point: 417.5°Cat760mmHg
• Flash Point: 206.3°C
• PSA: 82.69000
• Density: 1.239g/cm³
• LogP: 3.46420

Purity/Quality:

97% ^*data from raw suppliers

ETHYL-2-(BENZYLAMINO)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-(BENZYLAMINO)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE HYDROCHLORIDE

There total 4 articles about ETHYL 2-(BENZYLAMINO)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl-2-amino-4-methylthiazole-5-carboxylate (7210-76-6) + benzaldehyde (100-52-7) → ethyl 2-(benzylamino)-4-methyl-1,3-thiazole-5-carboxylate (15087-95-3)

Guidance literature:

ethyl-2-amino-4-methylthiazole-5-carboxylate; benzaldehyde; With iodine; In methanol; at 20 ℃;

With sodium tetrahydroborate; In methanol; at 20 ℃;

DOI:10.1111/cbdd.12686

Reference yield: 79.0%

ethyl acetoacetate (141-97-9) + N-benzylthiourea (621-83-0) → ethyl 2-(benzylamino)-4-methyl-1,3-thiazole-5-carboxylate (15087-95-3)

Guidance literature:

ethyl acetoacetate; With 1,3,5-tribromo-1,3,5-triazinane-2,4,6-trione; In water; at 70 ℃; for 0.333333h;

N-benzylthiourea; With 1,4-diaza-bicyclo[2.2.2]octane; In water; acetonitrile; at 70 ℃; for 0.333333h;

DOI:10.1055/s-0037-1610243

Reference yield:

ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 2-(benzylamino)-4-methyl-1,3-thiazole-5-carboxylate (15087-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 20 - 80 °C

2.1: iodine / methanol / 20 °C

2.2: 20 °C

With iodine; In methanol; ethanol;

DOI:10.1111/cbdd.12686

upstream raw materials:

ethyl 2-chloro-3-oxo-butyrate

N-benzylthiourea

ethyl-2-amino-4-methylthiazole-5-carboxylate

benzaldehyde

Downstream raw materials:

2-(benzylamino)-4-methyl-1,3-thiazole-5-carboxylic acid