N,N-di-n-Butyl-2-hydroxyacetamide

Base Information

• Chemical Name: N,N-di-n-Butyl-2-hydroxyacetamide
• CAS No.: 70785-78-3
• Molecular Formula: C10H21NO2
• Molecular Weight: 187.282
• European Community (EC) Number: 615-166-5
• DSSTox Substance ID: DTXSID40451678
• Nikkaji Number: J2.493.440C
• Wikidata: Q82271814
• Mol file: 70785-78-3.mol

Synonyms:N,N-di-n-Butyl-2-hydroxyacetamide;n,n-dibutyl-2-hydroxyacetamide;70785-78-3;SCHEMBL542744;DTXSID40451678;UQUCGKURBJKXPC-UHFFFAOYSA-N

Chemical Property of N,N-di-n-Butyl-2-hydroxyacetamide

Chemical Property:

• Vapor Pressure: 0.000204mmHg at 25°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 187.157228913
• Heavy Atom Count: 13
• Complexity: 129

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCN(CCCC)C(=O)CO

Technology Process of N,N-di-n-Butyl-2-hydroxyacetamide

There total 2 articles about N,N-di-n-Butyl-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.8%

4-oxo-2,2-dimethyl-1,3-dioxolane (4158-86-5) + dibutylamine (111-92-2) → N,N-di-n-butyl-2-hydroxyacetamide (70785-78-3)

Guidance literature:

In toluene; for 14h; Heating;

DOI:10.1055/s-2007-983762

Reference yield:

N,N-di-n-butyl-2-benzyloxyacetamide + pyrographite (7440-44-0) → N,N-di-n-butyl-2-hydroxyacetamide (70785-78-3)

Guidance literature:

In ethanol;

Reference yield:

N,N-di-n-butyl-2-hydroxyacetamide (70785-78-3) + 3,3-diphenyloxirane-2-carboxylic acid methyl ester (76527-25-8) → methyl 2-hydroxy-3-(N,N-di-n-butylcarbamoylmethoxy)-3,3-diphenylpropionate (224455-72-5)

Guidance literature:

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In dichloromethane;

upstream raw materials:

4-oxo-2,2-dimethyl-1,3-dioxolane

dibutylamine

pyrographite

Downstream raw materials:

methyl 2-hydroxy-3-(N,N-di-n-butylcarbamoylmethoxy)-3,3-diphenylpropionate