N,N-Diethyl-2-formyl-6-methoxybenzamide

Base Information

• Chemical Name: N,N-Diethyl-2-formyl-6-methoxybenzamide
• CAS No.: 70946-17-7
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• DSSTox Substance ID: DTXSID90499161
• Wikidata: Q82349704
• Mol file: 70946-17-7.mol

Synonyms:N,N-Diethyl-2-formyl-6-methoxybenzamide;70946-17-7;N,N-diethyl-2-formyl-6-methoxy-benzamide;SCHEMBL1029232;DTXSID90499161;RRJAYDOIDXXAQT-UHFFFAOYSA-N;MFCD20527268;AKOS030578406;AS-44594

Chemical Property of N,N-Diethyl-2-formyl-6-methoxybenzamide

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 235.12084340
• Heavy Atom Count: 17
• Complexity: 263

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C(=O)C1=C(C=CC=C1OC)C=O

Technology Process of N,N-Diethyl-2-formyl-6-methoxybenzamide

There total 5 articles about N,N-Diethyl-2-formyl-6-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-diethyl-2-formyl-6-methoxybenzamide (70946-17-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h;

N,N-diethyl-2-methoxybenzamide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 2.83333h;

N,N-dimethyl-formamide; In tetrahydrofuran; cyclohexane; for 0.5h;

Reference yield: 91.0%

N,N-diethyl-2-methoxybenzamide (51674-10-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-diethyl-2-formyl-6-methoxybenzamide (70946-17-7)

Guidance literature:

N,N-diethyl-2-methoxybenzamide; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; pentane; at -78 ℃; for 3h;

DOI:10.1021/ol400686f

Reference yield:

2-Methoxybenzoic acid (579-75-9) → N,N-diethyl-2-formyl-6-methoxybenzamide (70946-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: SOCl₂ / toluene / 2 h / Heating

2.1: diethyl ether / 1 h

3.1: t-BuLi; TMEDA / tetrahydrofuran / 1.5 h / -78 °C

3.2: 70 percent / tetrahydrofuran

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; toluene;

DOI:10.1055/s-2007-983841

upstream raw materials:

N,N-diethyl-2-methoxybenzamide

N,N-dimethyl-formamide

2-Methoxybenzoic acid

2-Methoxybenzoyl chloride

Downstream raw materials:

N,N-Diethyl-2-[hydroxy-((6R,8R)-8-hydroxy-6-methyl-5,6,7,8-tetrahydro-naphthalen-1-yl)-methyl]-6-methoxy-benzamide

N,N-Diethyl-2-hydroxymethyl-6-methoxy-benzamide

(+/-)-N,N-diethyl-2-(1-hydroxyheptyl)-6-methoxybenzamide

N,N-diethyl-2-heptanoyl-6-methoxybenzamide