4722-94-5

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H4ClNO4/c8-3-1-4(6(10)11)9-5(2-3)7(12)13/h1-2H,(H,10,11)(H,12,13)

Upstream product

• 3512-75-2 4-chloro-2,6-lutidine 
• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 499-51-4 Chelidamic acid 
• 53389-01-8 diethyl 4-chloropyridine-2,6-dicarboxylate 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 5371-70-0 dimethyl 4-chloro-2,6-pyridinedicarboxylate 
• 6317-46-0 1-ethyl-4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid 
• 41600-42-4 1-methyl-4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid 
• 99-32-1 chelidonic acid 
• 138-60-3 chelidamic acid 

Downstream Products

• 506423-80-9 4-iodo-pyridine-2,6-dicarboxylic acid 
• 499-51-4 Chelidamic acid 
• 5371-70-0 dimethyl 4-chloro-2,6-pyridinedicarboxylate 
• 3648-29-1 4-(dimethylamino)pyridine-2,6-dicarboxylic acid 
• 2683-49-0 4-amino-2,6-pyridinedicarboxylic acid 
• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 
• 293294-71-0 4-chloro-6-methoxycarbonylpyridine-2-carboxylic acid 
• 73353-47-6 C₂₁H₃₀ClNO₁₀*C₇H₉N*ClHO₄ 
• 73366-89-9 C₂₀H₂₉NO₁₀*C₇H₉N*ClHO₄ 
• 73353-51-2 C₁₅H₁₈ClNO₇*C₈H₁₁N*ClHO₄ 
• 73353-50-1 C₁₆H₂₁NO₈*C₈H₁₁N*ClHO₄ 
• 71124-59-9 C₁₅H₁₈ClNO₇*C₇H₉N*ClHO₄ 
• 71124-61-3 C₁₆H₂₁NO₈*C₇H₉N*CHNS 
• 71124-58-8 C₁₅H₁₈ClNO₇*C₇H₉N*CHNS 

Relevant academic research and scientific papers

Linking of antitumor trans NHC-Pt(II) complexes to G-quadruplex DNA ligand for telomeric targeting

G-quadruplex structures (G4) are promising anticancerous targets. A great number of small molecules targeting these structures have already been identified through biophysical methods. In cellulo, some of them are able to target either telomeric DNA and/o

Nucleophilic Substitution Reactions at Planar Four-co-ordinate Monoanionic Platinum(II) Complexes

The kinetics of displacement of chloride from complex anions of the type - (pydca = pyridine-2,6-dicarboxylate; R = H, Cl or OMe) by a number of anionic and neutral nucleophiles have been studied in aqueous solution, at 25.0 deg C, I = 0.50 mol dm-3 (LiClO4).Apart from the reactions with OH-, the reactivities of the substrates are not greatly sensitive to the nature of the substituent in the 4 position.Anionic nucleophiles can be as much as two orders of magnitude less reactive than neutral nucleophiles with similar n0Pt values.The rate law for the reaction with OH- takes the form -dln/dt = ks + k3->2, where ks is the first-order rate constant for the solvolytic pathway observed in all the substitution reactions, and where k3 is sensitive to the basicity of the nitrogen in the terdentate ligand.

Heavy metal complexes of 4-chlorodipicolinic acid - structural, spectral and thermal correlations

The ligand, 4-chloro-2,6-dipicolinic acid (H2PDA-Cl), and its two heavy metal complexes, [Ag(HDPA-Cl)(H2DPA-Cl)·2H2O] (1) and {[Cd(μ2-H2O)(H2O)(PDA-Cl)]}n (2), were prepared and then characterized by single-crystal X-ray diffraction. In addition, spectral and thermal correlations with structural results complete their solid-state description and facilitate complex 3 ([Pb(DPA-Cl)]) composition determinations. Complex 1 crystallizes in a monoclinic space group C2/c and each DPA-Cl ligand is tridentate to Ag(I) through the pyridine N and two monodentate carboxyl O atoms. The carboxy group with carbonyl C1 is semideprotonated and forms a symmetric hydrogen bond with a carboxy group of a neighboring complex. Complex 2 crystallizes in a triclinic lattice with space group P (Formula presented.) The Cd(II) ions are seven-coordinate and the coordination polyhedra can be described as a distorted pentagonal bipyramid. IR data are consistent with monodentate coordination of the carboxylate to Ag(I), Cd(II), and Pb(II) and observed wavenumber shifts confirm PDA-Cl ligand coordination to Pb(II) in 3. Thermal stability of anhydrous complexes indicates the metal–ligand interactions. The thermal stability of prepared compounds is reflected by the strength of interaction between metal–ligand and hydrogen bonds.

Synthesis, characterization, and spectroscopic properties of three novel pentadentate copper(II) complexes related to the metalchelating inhibitors against DNA binding with HIV-EP1

Three potentially five-coordinate peptide ligands having a pyridine and two histidine moieties, were synthesized to study their copper(II) complexation. Blue copper(II) complexes with deprotonated amide groups were isolated from methanolic solutions of the corresponding ligands with equimolar Cu(OAc) 2·H2O. The structures of two of them were determined by X-ray crystallography. The Cu is coordinated to five nitrogen atoms in both complexes; the coordination geometry was a distorted square pyramid in one, and intermediate between a square pyramid and trigonal bipyramid in the other. EPR spectra in frozen methanol solutions at 77 K as well as visible absorption spectra indicate that the distortion of the geometry around the copper is reduced by the introduction of an alkylamine substituent on the pyridine of the ligand and that the substituted complexes distort toward trigonal bipyramidal geometry compared to the unsubstituted one in solution. The Royal Society of Chemistry 2001.

A formal anti-Markovnikov hydroalkoxylation of allylic alcohols with a ruthenium catalyst

Hydroalkoxylation of C-C double bonds was achieved through the use of a ruthenium catalyst. The reaction of allylic alcohols with nucleophilic alcohols was carried out in the presence of a ruthenium catalyst prepared by RuClH(CO)(PPh3)3 and 2,6-bis(n-butyliminomethyl)-4-(piperidin-1-yl)pyridine under mild reaction conditions to afford the corresponding γ-alkoxypropanols in good yield.

Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1

The efficacy of β-lactam antibiotics is threatened by the emergence and global spread of metallo-β-lactamase (MBL) mediated resistance, specifically New Delhi metallo-β-lactamase-1 (NDM-1). By utilization of fragment-based drug discovery (FBDD), a new class of inhibitors for NDM-1 and two related β-lactamases, IMP-1 and VIM-2, was identified. On the basis of 2,6-dipicolinic acid (DPA), several libraries were synthesized for structure-activity relationship (SAR) analysis. Inhibitor 36 (IC50 = 80 nM) was identified to be highly selective for MBLs when compared to other Zn(II) metalloenzymes. While DPA displayed a propensity to chelate metal ions from NDM-1, 36 formed a stable NDM-1:Zn(II):inhibitor ternary complex, as demonstrated by 1H NMR, electron paramagnetic resonance (EPR) spectroscopy, equilibrium dialysis, intrinsic tryptophan fluorescence emission, and UV-vis spectroscopy. When coadministered with 36 (at concentrations nontoxic to mammalian cells), the minimum inhibitory concentrations (MICs) of imipenem against clinical isolates of Eschericia coli and Klebsiella pneumoniae harboring NDM-1 were reduced to susceptible levels.

Modified Colorants and Inkjet Ink Compositions Comprising Modified Colorants

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Luminescent lanthanide complex, and articles and inks containing the luminescent complex

Luminescent lanthanide complex and inks containing the complex as well as its method of production and article including the complex, wherein the complex includes the formula: wherein M is chosen from the alkali cations Li+, Na+, K+, Rb+ and Cs+ and mixtures thereof and is present to neutralize charge of the complex; wherein Ln is chosen from the trivalent rare-earth cations of Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, and Yb and mixtures thereof; wherein R is a C5 to C6 heteroaryl: wherein Y is an optionally substituted C3-C8 heterocycloalkyl moiety linked to R by an N atom; wherein n is an integer of 3 or 5; and wherein x is an integer of 0 or 1.

Unprecedented strong lewis bases - Synthesis and methyl cation affinities of dimethylamino-substituted terpyridines

A versatile method for the synthesis of functionalized 2,2′:6′, 2″-terpyridines by assembly of the terminal pyridine rings is presented. The cyclization precursors - bis-β-ketoenamides - are prepared from 4-substituted 2,6-pyridinedicarboxylic acids and a

LUMINESCENT LANTHANIDE COMPLEX, AND ARTICLES AND INKS CONTAINING THE LUMINESCENT COMPLEX

Luminescent lanthanide complex and inks containing the complex as well as its method of production and article including the complex, wherein the complex includes the formula: wherein M is chosen from the alkali cations Li+, Na+, K+, Rb+ and Cs+ and mixtures thereof and is present to neutralize charge of the complex; wherein Ln is chosen from the trivalent rare-earth cations of Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, and Yb and mixtures thereof; wherein R is a C5 to C6 heteroaryl: wherein Y is an optionally substituted C3-C8 heterocycloalkyl moiety linked to R by an N atom; wherein n is an integer of 3 or 5; and wherein x is an integer of 0 or 1.