1333-82-0

Basic information

• Product Name: Chromium(VI) trioxide
• Synonyms: Chromia(CrO₃);Chromic anhydride;Chromic trioxide;Chromiumtrioxide;Chromium(VI) oxide;Chromium(VI) trioxide;Monochromium trioxide;Chromiun(Ⅵ)oxide
• CAS NO: 1333-82-0
• Molecular Formula: CrO₃
• Molecular Weight: 99.9943
• EINECS: 215-607-8
• Mol File: 1333-82-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 196℃
• Boiling Point: 330 °C
• Flash Point: 250°C
• Appearance: dark red crystals or powder
• Density: 2.7 g/cm³
• Water Solubility: 1660 g/L (20℃)
• CAS DataBase Reference: Chromium(VI) trioxide(CAS DataBase Reference)
• NIST Chemistry Reference: Chromium(VI) trioxide(1333-82-0)
• EPA Substance Registry System: Chromium(VI) trioxide(1333-82-0)

Safety Data

• Hazard Codes: O:Oxidizing agent
• Statements: R24/25:; R26:; R35:; R42/43:; R45:; R46:; R48/23:; R50/53:; R62:
• Safety Statements: S45:; S53:; S60:; S61:
• RIDADR: 1463
• HazardClass: 5.1
• PackingGroup: II
• Hazardous Substances Data: 1333-82-0(Hazardous Substances Data)

Usage

General Description

Chromium(VI) trioxide is a powerful oxidizing agent and the most stable of the chromium trioxides. It is an inorganic compound with the formula CrO3 and is a dark red to brown solid. Chromium(VI) trioxide has been classified as a known human carcinogen and can be absorbed into the body by inhalation, through skin, and by ingestion which can lead to toxicity. It typically finds use in the production of chromium plating, corrosion inhibitors, and a variety of synthetic organic chemistry reactions, most notably being used extensively in the manufacture of dyes and pigments. Furthermore, its strong oxidizing properties make it useful in various cleaning and disinfection applications.

InChI:InChI=1/Cr.3O/q+6;3*-2

Synthetic route

chromium (7440-47-3) + oxygen (80937-33-3) → chromium(VI) oxide (1333-82-0)

Conditions	Yield
In gaseous matrix laser-vaporized Cr atoms; O2 seeded in He; underwent supersonic expansion;

chromium chloride + water (7732-18-5) → chromium(VI) oxide (1333-82-0)

Conditions	Yield
Stage #1: chromium chloride; water With ammonia pH=7.5; Stage #2: at 300℃; for 8h; Calcination;

chromium(VI) oxide (1333-82-0) + 3-methyl-6-benzyloxazolo[4,5-b]pyridin-2(3H)-one (175424-48-3) → 3-methyl-6-benzoyloxazolo[4,5-b]pyridin-2(3H)-one (175424-00-7)

Conditions	Yield
With tert.-butylhydroperoxide In dichloromethane	82%

2-Bromo-4-picoline (4926-28-7) + chromium(VI) oxide (1333-82-0) → 2-bromoisonicotinic acid (66572-56-3)

Conditions	Yield
In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid	82%

3N-HCl + 2-bromo-5-chlorotoluene (14495-51-3) + chromium(VI) oxide (1333-82-0) → 2-bromo-5-chlorobenzaldehyde (174265-12-4)

Conditions	Yield
With sulfuric acid In ethanol; water; acetic anhydride	77%

2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,6-difluoro-2,4,5,6-tetrahydrocyclopenta[c]pyrazole (333995-39-4) + chromium(VI) oxide (1333-82-0) → 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,6-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one (333995-42-9)

Conditions	Yield
In hexane; acetic acid; ethyl acetate	76%

hydrogenchloride (7647-01-0) + 2-methylquinoline (91-63-4) + chromium(VI) oxide (1333-82-0) → quinaldinium chlorochromate

Conditions	Yield
In water at 0℃; for 2.5h;	72%

chromium(VI) oxide (1333-82-0) + 1,11-dihydroxy-3-dodecyne (100991-28-4) → 11-hydroxy-3-dodecynoic acid (87519-39-9)

Conditions	Yield
In hexane; sulfuric acid; water; acetone	68%

pentrinitrol (1607-17-6) + chromium(VI) oxide (1333-82-0) → 2-Nitryloxy-2,2-bis(nitryloxymethyl)propionsaeure (67406-79-5)

Conditions	Yield
With sulfuric acid	60%

2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,5-difluoro-2,4,5,6-tetrahydrocyclopenta[c]pyrazole (333995-54-3) + chromium(VI) oxide (1333-82-0) → 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,5-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one (333995-57-6)

Conditions	Yield
In hexane; acetic acid; ethyl acetate	50%

androstenediol-3,17-diacetate (2099-26-5) + chromium(VI) oxide (1333-82-0) → 3β, 17β-diacetoxyandrost-5-ene-7-one (13209-60-4)

Conditions	Yield
In methanol; CrO3; acetic acid	20%

water (7732-18-5) + chromium(VI) oxide (1333-82-0) → chromic acid (7738-94-5)

chromium(VI) oxide (1333-82-0) + N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine (103057-44-9) → tert-butyl 2-oxopyrrolidine-1-carboxylate (85909-08-6)

Conditions	Yield
With pyridine; acetic anhydride In dichloromethane; ethyl acetate

7-benzyl-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (499790-78-2) + chromium(VI) oxide (1333-82-0) → 7-benzoyl-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (499792-53-9)

Conditions	Yield
In acetic anhydride

jones reagent + 3-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]propan-1-ol (350231-40-2) + chromium(VI) oxide (1333-82-0) → 3-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]propanoic acid (350231-41-3)

Conditions	Yield
With sulfuric acid In water; acetone

2-chloro-2'-methoxy-5-nitrobenzhydrol (173736-10-2) + chromium(VI) oxide (1333-82-0) → 2-chloro-2'-methoxy-5-nitrobenzophenone (173736-11-3)

Conditions	Yield
In methanol; dichloromethane; water; acetic acid
In methanol; dichloromethane; water; acetic acid
In methanol; dichloromethane; water; acetic acid
In methanol; dichloromethane; water; acetic acid

3-(4-hydroxytetrahydrofuran-3-yloxy)-4-methoxybenzonitrile + chromium(VI) oxide (1333-82-0) → 3-(tetrahydrofuran-4-on-3-yloxy)-4-methoxybenzonitrile

Conditions	Yield
With pyridine; acetic anhydride In dichloromethane; water

ethyl 3-trifluoromethyl-4-[(4-chloro-2-nitrophenyl)(hydroxy)methyl]1H-pyrazole-5-carboxylate + chromium(VI) oxide (1333-82-0) → ethyl 4-(4-chloro-2-nitrobenzoyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylate

Conditions	Yield
With pyridine In dichioromethane; dichloromethane	1.33 g (82%)

sodium hydrogensulfate monohydrate (10034-88-5) + methyl (1-hydroxymethyl-1,2,3,4-tetrahydronaphthalen-5-yl) oxyacetate + chromium(VI) oxide (1333-82-0) → Methyl (1-formyl-1,2,3,4-tetrahydronaphthalen-5-yl) oxyacetate

Conditions	Yield
With pyridine In dichloromethane

chromium(VI) oxide (1333-82-0) + N-<2-(2-hydroxyethoxy)ethyl>benzamide (124243-65-8) → 2-(2-benzamidoethoxy)-acetic acid (142489-50-7)

Conditions	Yield
In sulfuric acid; acetone	2.5 g (74.7%)

2-acetylamino-3-(2-chlorobenzoyl)-5,6-dihydro-7H-benzo[b]thiophene (114777-54-7) + chromium(VI) oxide (1333-82-0) → 2-acetylamino-3-(2-chlorobenzoyl)-5,6-dihydro-4H-benzo[b]thiophen-7-one

Conditions	Yield
In water

5α-bromo-6β-fluoro-17α-hydroxy-16α-methyl-pregnane-3,20-dione + 5-bromo-6β-fluoro-3β,17-dihydroxy-16-methyl-pregnan-20-one + chromium(VI) oxide (1333-82-0) + isopropyl alcohol (67-63-0) → 6α-fluoro-17α-hydroxy-16α-methyl-4-pregnene-3,20-dione

Conditions	Yield
With hydrogen bromide; sodium acetate; chromic acid In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid; water; acetic acid; acetone

5-benzyl-1,2-O-isopropylidene-α-D-xylofuranose (23202-83-7, 2592-42-9) + chromium(VI) oxide (1333-82-0) → 5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose (34311-63-2)

Conditions	Yield
With pyridine In dichloromethane

chromium(VI) oxide (1333-82-0) + nimodipin (66085-59-4) → Nimodipine Oxidized (85677-93-6)

Conditions	Yield
In acetic acid
In acetic acid

chromium(VI) oxide (1333-82-0) + N-(6-Phenoxy-5-indanyl)-methansulfonamid (75370-30-8) → N-[1-oxo-6-phenoxyindan-5-yl]methanesulfonamide (75360-85-9)

Conditions	Yield
With acetic anhydride In water; acetic acid

17β-acetoxy-3β-benzoyloxy-15β,16β-methylene-5-androstene (81721-19-9) + chromium(VI) oxide (1333-82-0) + tert-butyl alcohol (75-65-0) → 17β-acetoxy-3β-benzoyloxy-15β,16β-methylene-5-androsten-7-one (81721-20-2)

Conditions	Yield
With acetic anhydride; acetic acid In tetrachloromethane

α-ethyl-1-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole-5-methanol (119085-08-4) + chloroform (67-66-3) + chromium(VI) oxide (1333-82-0) → 1-[1-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazol-5-yl]-1-propanone

Conditions	Yield
With pyridine In methanol; dichloromethane	2.2 parts (12.3%)

jones reagent + methanoate + chromium(VI) oxide (1333-82-0) + sodium carbonate (497-19-8) + cephalothin (153-61-7) → 3-formyl-7-(thien-2-ylacetamido)-2-cephem-4-carboxylic acid (49769-48-4)

Conditions	Yield
With hydrogenchloride In pyridine; concentrated H2 SO4; water; acetic anhydride; ethyl acetate; acetone

(4aS)-7-methoxy-2t-methyl-2c-hydroxymethyl-1t-ethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene (39780-02-4) + chromium(VI) oxide (1333-82-0) → 3-methoxy-16,17-seco-estra-1,3,5(10)-trien-17-al (39780-07-9)

Conditions	Yield
In pyridine

jones reagent + 2,3,5-trimethyl-6-(6'-acetoxy-1'-hydroxyhexyl)-1,4-benzoquinone (58186-18-8) + chromium(VI) oxide (1333-82-0) → 2,3,5-trimethyl-6-(6'-acetoxy-1'-oxohexyl)-1,4-benzoquinone (58186-19-9)

Conditions	Yield
In sulfuric acid; acetone

21-acetoxy-11α-hydroxy-6,16α-dimethyl-1,4,6-pregnatriene-3,20-dione (67977-35-9) + chromium(VI) oxide (1333-82-0) → 21-acetoxy-6,16α-dimethyl-1,4,6-pregnatriene-3,11,20-trione (67977-36-0)

Conditions	Yield
With sodium hydrogencarbonate In acetic acid

3-Oxa-1-(tetrahydropyran-2-yloxy)decan-9-ol + chromium(VI) oxide (1333-82-0) → 3-oxa-1-(tetrahydropyran-2-yloxy)decan-9-one

Conditions	Yield
In jones reagent; sulfuric acid; water; isopropyl alcohol; acetone

Upstream product

• 16284-59-6 chromium chloride 
• 7732-18-5 water 
• 7440-47-3 chromium 
• 80937-33-3 oxygen 

Downstream Products

• 66572-56-3 2-bromoisonicotinic acid 
• 34311-63-2 5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose 
• 13209-60-4 3β, 17β-diacetoxyandrost-5-ene-7-one 
• 58186-19-9 2,3,5-trimethyl-6-(6'-acetoxy-1'-oxohexyl)-1,4-benzoquinone 
• 81721-20-2 17β-acetoxy-3β-benzoyloxy-15β,16β-methylene-5-androsten-7-one 
• 75360-85-9 N-[1-oxo-6-phenoxyindan-5-yl]methanesulfonamide 
• 85677-93-6 Nimodipine Oxidized 
• 175424-00-7 3-methyl-6-benzoyloxazolo[4,5-b]pyridin-2(3H)-one 
• 142489-50-7 2-(2-benzamidoethoxy)-acetic acid 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 333995-42-9 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,6-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one 
• 333995-57-6 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,5-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one 
• 173736-11-3 2-chloro-2'-methoxy-5-nitrobenzophenone 
• 350231-41-3 3-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]propanoic acid 

Relevant articles and documents

Electronic structure of chromium oxides, CrOn- and CrOn (n=1-5) from photoelectron spectroscopy and density functional theory calculations

A comprehensive theoretical and experimental investigation of CrOn- (n=1-5) and their corresponding neutral species was carried out. Photodetachment photoelectron spectra were obtained for the anions produced from a laser vaporization cluster source at various photon energies. Calculated adiabatic and vertical binding energies of CrOn- showed good agreement with the experimental values. It was shown that theoretical calculations are very helpful in interpretations of the photoelectron spectra of the anions, in understanding the electronic and geometrical structures of their ground and excited states, and chemical bonding for both the anions and the neutral species.