Technology Process of Acetic acid, trifluoro-, (1R,2S,4S)-3-oxo-2-phenylbicyclo[2.2.1]hept-2-yl
ester, rel-
There total 11 articles about Acetic acid, trifluoro-, (1R,2S,4S)-3-oxo-2-phenylbicyclo[2.2.1]hept-2-yl
ester, rel- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 23 percent / KNH2, liquid NH3 / diethyl ether / 3.5 h / Irradiation
2: 1.) LDA / 1.) Et2O, -78 deg C -> 40 deg C, 2.) room temperature, 2 h 15 min
3: MCPBA / CH2Cl2 / 2.25 h / -20 - -10 °C
4: NaOMe / methanol; H2O / 0.25 h / Heating
5: 98 percent / pyridine / 0.25 h / 0 °C
With
pyridine; ammonia; sodium methylate; potassium amide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00362a017
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 23 percent / KNH2, liquid NH3 / diethyl ether / 3.5 h / Irradiation
2: 1.) LDA / 1.) Et2O, -78 deg C -> 40 deg C, 2.) room temperature, 2 h 15 min
3: MCPBA / CH2Cl2 / 2.25 h / -20 - -10 °C
4: NaOMe / methanol; H2O / 0.25 h / Heating
5: 98 percent / pyridine / 0.25 h / 0 °C
6: NaOAc, Ac2O / 90 °C / various temperatures; solvolyses of α-keto norbornyl trifluoroacetates and triflates, endo/exo rate ratio
With
pyridine; ammonia; sodium methylate; sodium acetate; acetic anhydride; potassium amide; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00362a017
