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1860-60-2

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1860-60-2 Usage

General Description

3-Benzyl-oxy-4-methoxybenzyl alcohol is a chemical compound belonging to the class of organic compounds known as benzyl alcohols, characterized by an aryl group connected to a hydroxyl (-OH) group by a CH2 group. Its systematic name is 3-(benzyloxy)-4-methoxybenzenemethanol. 3-BENZYLOXY-4-METHOXYBENZYL ALCOHOL is commonly used in the field of chemistry as a reagent, an intermediate, or a building block in the synthesis of more complex molecules, especially in pharmaceutical and materials research. Its presence is not naturally occurring and must be synthesized in labs. As with many chemical substances, proper safety measures should be taken when handling and storing this compound to prevent harm due to improper use or exposure.

Check Digit Verification of cas no

The CAS Registry Mumber 1860-60-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,6 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1860-60:
(6*1)+(5*8)+(4*6)+(3*0)+(2*6)+(1*0)=82
82 % 10 = 2
So 1860-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H16O3/c1-17-14-8-7-13(10-16)9-15(14)18-11-12-5-3-2-4-6-12/h2-9,16H,10-11H2,1H3

1860-60-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name [3-(Benzyloxy)-4-methoxyphenyl]methanol

1.2 Other means of identification

Product number -
Other names (3-BENZYLOXY-4-METHOXY-PHENYL)-METHANOL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1860-60-2 SDS

1860-60-2Relevant articles and documents

PHENANTHROINDOLIZIDINE AND PHENANTHROQUINOLIZIDINE ALKALOID HAVING A HYDROXYL GROUP ON THE PHENANTHRENE RING THEREOF, PREPARATION METHOD AND USE THEREOF

-

Paragraph 0225-0228, (2017/07/01)

A phenanthroindolizidine and phenanthroquinolizidine alkaloid having a hydroxyl group on the phenanthrene ring thereof was synthesized, which exhibits potent activity as an anticancer agent against, such as breast cancer, lung cancer, and prostate cancer.

Designing new analogs for streamlining the structure of cytotoxic lamellarin natural products

Tangdenpaisal, Kassrin,Worayuthakarn, Rattana,Karnkla, Supatra,Ploypradith, Poonsakdi,Intachote, Pakamas,Sengsai, Suchada,Saimanee, Busakorn,Ruchirawat, Somsak,Chittchang, Montakarn

, p. 925 - 937 (2015/03/31)

Despite the therapeutic potential of marine-derived lamellarin natural products, their preclinical development has been hampered by their lipophilic nature, causing very poor aqueous solubility. In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the additional structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds.

Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents

Zuo, Sai-Jie,Li, Sen,Yu, Rui-Hong,Zheng, Guo-Xun,Cao, Yong-Xiao,Zhang, San-Qi

supporting information, p. 5597 - 5601 (2015/01/08)

In the present study, a series of 3-benzylquinazolin-4(3H)-ones were synthesized and characterized. Their vasodilative effects were evaluated by wire myograph on isolated rat mesenteric arterial ring induced contraction with 60 mM KCl. The SAR of target compounds was discussed preliminarily. Among these compounds, 2a and 2c displayed potent vasodilatation action and could compete significantly the rat mesenteric arterial rings induced contraction with phenylephrine. Compounds 2a and 2c were further tested for their antihypertensive effects in SHR by oral administration. The results indicated that 2a and 2c could reduce significantly both diastolic and systolic blood pressure. Moreover, 2c displayed antihypertensive effect in a dose dependent manner, and could maintain the effects for 6 h at a dosage of 4.0 mg/kg. These findings suggest that the title compounds are novel vasodilative agents, representing a novel series of promising antihypertensive agents.

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