NULL

Base Information

• Chemical Name: NULL
• CAS No.: 71797-90-5
• Molecular Formula: C12H11ClO4S
• Molecular Weight: 286.73100
• Mol file: 71797-90-5.mol

Synonyms:3-chloro-5,6-dimethoxy-benzo[b]thiophene-2-carboxylic acid methyl ester;

Chemical Property of NULL

Chemical Property:

• PSA: 73.00000
• LogP: 3.35850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NULL

There total 4 articles about NULL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methanol (67-56-1) + methyl 3-chloro-5,6-dimethoxybenzo[b]thiophene-2-carboxylate (70262-57-6) → methyl 3-chloro-5,6-dimethoxybenzo[b]thiophene-2-carboxylate (71797-90-5)

Guidance literature:

In methanol; for 24h; Reflux;

Reference yield:

3,4-dimethoxycinnamic acid (2316-26-9) → methyl 3-chloro-5,6-dimethoxybenzo[b]thiophene-2-carboxylate (71797-90-5)

Guidance literature:

3,4-dimethoxycinnamic acid; With thionyl chloride; In chlorobenzene; at 20 ℃; for 0.5h;

With pyridine; In chlorobenzene; for 24h; Heating / reflux;

With methanol; In chlorobenzene; for 1h; Heating / reflux;

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → methyl 3-chloro-5,6-dimethoxybenzo[b]thiophene-2-carboxylate (71797-90-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine; piperidine / 4 h / Reflux

2.1: thionyl chloride / chlorobenzene / 0.5 h / 20 °C

2.2: 24 h / Reflux

3.1: methanol / 24 h / Reflux

With piperidine; pyridine; thionyl chloride; In methanol; chlorobenzene;

upstream raw materials:

3,4-dimethoxycinnamic acid

methanol

methyl 3-chloro-5,6-dimethoxybenzo[b]thiophene-2-carboxylate

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

methyl 5,6-dimethoxybenzo[b]thiophene-2-carboxylate

Refernces

• 1、 -. "NEW PHARMACEUTICAL COMPOUNDS". Page/Page column 18. . Retrieved 2008/06/13.