N-(2-aminophenyl)benzamide

Base Information

• Chemical Name: N-(2-aminophenyl)benzamide
• CAS No.: 721-47-1
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• Hs Code.: 2924299090
• European Community (EC) Number: 829-819-9
• DSSTox Substance ID: DTXSID60353948
• Nikkaji Number: J79.925D
• Wikidata: Q82131822
• ChEMBL ID: CHEMBL405072
• Mol file: 721-47-1.mol

Synonyms:N-(2-aminophenyl)benzamide;721-47-1;2'-AMINOBENZANILIDE;Benzamide, N-(2-aminophenyl)-;CHEMBL405072;Oprea1_478192;MLS000084661;SCHEMBL407834;N-(2-amino-phenyl)-benzamide;DTXSID60353948;RFDVMOUXHKTCDO-UHFFFAOYSA-N;HMS2355D18;BDBM50232046;STL497474;AKOS000133162;SMR000019009;CS-0246108;EN300-31745;E87875;A826515;AE-641/00785046;SR-01000389415;SR-01000389415-1;Z239120458

Chemical Property of N-(2-aminophenyl)benzamide

Chemical Property:

• Melting Point: 150 °C
• Boiling Point: 293.2±23.0 °C(Predicted)
• PKA: 13.12±0.70(Predicted)
• PSA: 58.61000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 3.48630
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.094963011
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

95% ^*data from raw suppliers

N-(2-Aminophenyl)benzamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

Technology Process of N-(2-aminophenyl)benzamide

There total 32 articles about N-(2-aminophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-nitrophenyl)benzanilide (728-90-5) → 2'-Aminobenzanilid (721-47-1)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In methanol;

DOI:10.1016/j.tetlet.2009.11.080

Reference yield: 100.0%

1,2-diamino-benzene (95-54-5) + benzoyl dimethyl phosphate sodium salt → 2'-Aminobenzanilid (721-47-1)

Guidance literature:

In water; at 80 ℃; for 16h; Sealed tube;

DOI:10.1039/c3ra46749j

Reference yield: 96.0%

2- benzoylaminoazobenzene (7310-83-0) → 2'-Aminobenzanilid (721-47-1)

Guidance literature:

With iron; acetic acid; In ethanol; at 20 ℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere;

upstream raw materials:

N-(2-nitrophenyl)benzanilide

(2-aminophenyl)(phenyl)methanone

benzoyl cyanide

1,2-diamino-benzene

Downstream raw materials:

2-m-tolylazo-aniline

N-(2-(ferrocenecarboxamido)phenyl)benzamide

1-(2-(benzamido)phenyl)-3-ferrocenylurea

N-(2-benzamidophenyl)quinoxaline-2-carboxamide

Refernces

• 1、 Routholla, Ganesh,Pulya, Sravani,Patel, Tarun,Abdul Amin, Sk.,Adhikari, Nilanjan,Biswas, Swati,Jha, Tarun,Ghosh, Balaram. "Synthesis, biological evaluation, and molecular docking analysis of novel linker-less benzamide based potent and selective HDAC3 inhibitors". . . Retrieved 2021.
• 2、 Tang, Yan-Ling,Li, Mei-Ling,Gao, Jin-Chun,Sun, Yun,Qu, Lu,Huang, Feng,Mao, Ze-Wei. "Copper-catalyzed regioselective 2-amination of o-haloanilides with aqueous ammonia". supporting information. . Retrieved 2021/04/02.