2-Phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-Phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole
CAS No.:724434-37-1
Molecular Formula:C₁₅H₉F₃N₂O
Molecular Weight:290.244
Hs Code.:
DSSTox Substance ID:DTXSID70357336
Wikidata:Q82137221
Mol file:724434-37-1.mol

Synonyms:2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole;724434-37-1;AP-501/42682740;2-Phenyl-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole;DTXSID70357336

Suppliers and Price of 2-Phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 2-Phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Chemical Property:

PSA：38.92000
LogP:4.42240
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:290.06669740
Heavy Atom Count:21
Complexity:336

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NN=C(O2)C3=CC=C(C=C3)C(F)(F)F

Technology Process of 2-Phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

There total 6 articles about 2-Phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 613-94-5
benzoic acid hydrazide

: 166539-79-3
2,3,4,5,6-pentafluorophenyl 4-(trifluoromethyl)benzoate

: 724434-37-1
2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multistep reaction;
DOI:10.1016/j.tet.2006.08.016

Reference yield:

: 100-47-0
benzonitrile

: 724434-37-1
2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; zinc dibromide / water / 24 h / Reflux

2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; cesiumhydroxide monohydrate / toluene / 24 h / 120 °C / Inert atmosphere; Sealed tube

With sodium azide; cesiumhydroxide monohydrate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc dibromide; In water; toluene;
DOI:10.1002/adsc.201500778

Reference yield:

: 455-18-5
4-CF₃C₆H₄CN

: 724434-37-1
2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; zinc dibromide / water / 24 h / Reflux

2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; cesiumhydroxide monohydrate / toluene / 24 h / 120 °C / Inert atmosphere; Sealed tube

With sodium azide; cesiumhydroxide monohydrate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc dibromide; In water; toluene;
DOI:10.1002/adsc.201500778