Technology Process of 4-Penten-2-ol, 1-[(4-methoxyphenyl)methoxy]-, (2S)-
There total 15 articles about 4-Penten-2-ol, 1-[(4-methoxyphenyl)methoxy]-, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide;
In
tetrahydrofuran;
at -20 ℃;
for 0.166667h;
DOI:10.1055/s-2006-950424
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); tri-n-butyl-tin hydride;
In
dichloromethane;
at 24 ℃;
for 0.333333h;
DOI:10.1016/j.tet.2005.05.073
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 99 percent / NaH; TBAI / tetrahydrofuran / 16 h / 24 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
2.2: 79 percent / tetrahydrofuran; hexane / 1 h / -78 °C
3.1: 26 percent / DIBAH / CH2Cl2; hexane / 0.75 h / -78 °C
4.1: 64 percent / LAH / tetrahydrofuran / 26 h / -20 °C
5.1: (-)-DET; Ti(O-iPr)4; TBHP / CH2Cl2 / 60 h / -20 °C
6.1: SO3*pyridine; Et3N; DMSO / CH2Cl2 / 1 h / 24 °C
7.1: NaHMDS / tetrahydrofuran / 1 h / 24 °C
7.2: 59.8 percent / tetrahydrofuran / 19 h / -78 - 24 °C
8.1: 95 percent / Pd(PPh3)4; Bu3SnH / CH2Cl2 / 0.33 h / 24 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; pyridine-SO3 complex; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; (-)-diethyl tartrate; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane;
5.1: Katsuki-Sharpless asymmetric epoxidation / 7.2: Wittig reaction;
DOI:10.1016/j.tet.2005.05.073
