Triglyme

Base Information

• Chemical Name: Triglyme
• CAS No.: 112-49-2
• Deprecated CAS: 70992-85-7,2377493-99-5
• Molecular Formula: C8H18O4
• Molecular Weight: 178.229
• Hs Code.: 29094990
• European Community (EC) Number: 203-977-3
• ICSC Number: 1570
• NSC Number: 66400
• UNII: 32YXG88KK0
• DSSTox Substance ID: DTXSID8026224
• Nikkaji Number: J5.127F
• Wikipedia: Triethylene_glycol_dimethyl_ether
• Wikidata: Q2453066
• Metabolomics Workbench ID: 56588
• ChEMBL ID: CHEMBL1235255
• Mol file: 112-49-2.mol

Synonyms:triethylene glycol dimethyl ether;triglyme

Chemical Property of Triglyme

Chemical Property:

• Appearance/Colour: Clear colorless liquid with a mild ethereal odor
• Vapor Pressure: 0.539mmHg at 25°C
• Melting Point: - 45 °C(lit.)
• Refractive Index: n20/D 1.423(lit.)
• Boiling Point: 216 °C at 760 mmHg
• Flash Point: 110.6 °C
• PSA: 36.92000
• Density: 0.958 g/cm³
• LogP: 0.31240
• Storage Temp.: Refrigerator
• Sensitive.: Hygroscopic
• Solubility.: >1000g/l soluble
• Water Solubility.: Soluble
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 178.12050905
• Heavy Atom Count: 12
• Complexity: 67.5

Purity/Quality:

99% ^*data from raw suppliers

Triglyme ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 61-19-62
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Glycol Ethers (Glymes)
• Canonical SMILES: COCCOCCOCCOC
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
• Effects of Long Term Exposure: Animal tests show that this substance possibly causes toxicity to human reproduction or development.
• Uses: Triethylene glycol dimethyl ether is used as a solvent for gases and coupling immiscible liquid. It is also used to prepare perfluoro-triethyleneglycoldimethylether. Triethylene glycol dimethyl ether may be used as an analytical standard for the quantification of the analyte in water samples using in vitro bioassays and chemical screening technique. Labelled Triglyme. It is used as a solvent.

Technology Process of Triglyme

There total 18 articles about Triglyme which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(2,5-dioxahexylsulfonyl)benzene → Triethylene glycol dimethyl ether (112-49-2)

Guidance literature:

With sodium amalgam; In benzene; Heating;

Reference yield: 75.0%

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → 1,2-dimethoxyethane (110-71-4) + Triethylene glycol dimethyl ether (112-49-2) + 2-methoxy-ethanol (109-86-4,95507-80-5) + diethylene glycol dimethyl ether (111-96-6)

Guidance literature:

5%-palladium/activated carbon; nickel; at 220 ℃; for 10h; under 2250.23 Torr;

Reference yield: 33.0%

dimethyl sulfate (77-78-1) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → triethylene glucol monomethyl ether (112-35-6,95507-80-5) + Triethylene glycol dimethyl ether (112-49-2)

Guidance literature:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol; With sodium hydroxide; at 55 - 60 ℃; for 0.166667h;

dimethyl sulfate; at 55 - 60 ℃; for 6h;

DOI:10.1039/c3ra46704j

upstream raw materials:

1,1,2,2-tetrakis-(2-methoxy-ethoxy)-ethane

methyl iodide

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

dimethyl sulfate

Downstream raw materials:

F-triethylene glycol dimethyl ether

C₄₆H₆₁BrO₁₂

3,6,9-trioxadecyl bromide

4,4'-divinyl-biphenyl