2-Amino-3,5-diphenylpyridine

Base Information

• Chemical Name: 2-Amino-3,5-diphenylpyridine
• CAS No.: 726138-31-4
• Molecular Formula: C17H14N2
• Molecular Weight: 246.312
• DSSTox Substance ID: DTXSID30468775
• Wikidata: Q82296168
• Mol file: 726138-31-4.mol

Synonyms:3,5-diphenylpyridin-2-amine;726138-31-4;2-AMINO-3,5-DIPHENYLPYRIDINE;3,5-Diphenyl-pyridin-2-ylamine;SCHEMBL971373;3,5-Diphenylpyridin-2-ylamine;3,5-diphenyl-2-amino-pyridine;SCHEMBL19007094;DTXSID30468775;SMHSUJBAQQTWHF-UHFFFAOYSA-N;MFCD11044261;AS-6468;FT-0727598

Chemical Property of 2-Amino-3,5-diphenylpyridine

Chemical Property:

• PSA: 38.91000
• LogP: 4.57900
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 246.115698455
• Heavy Atom Count: 19
• Complexity: 266

Purity/Quality:

97% ^*data from raw suppliers

3,5-Diphenylpyridin-2-ylamine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CC=CC=C3

Technology Process of 2-Amino-3,5-diphenylpyridine

There total 4 articles about 2-Amino-3,5-diphenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-amino-3,5-dibromopyridine (35486-42-1) + phenylboronic acid (98-80-6) → 2-amino-3,5-diphenyl-pyridine (726138-31-4)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; ethylene glycol; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.11.018

Reference yield: 68.0%

→ 2-amino-3,5-diphenyl-pyridine (726138-31-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; toluene; Reflux;

Reference yield:

bis-triphenylphosphine-palladium(II) chloride (13965-03-2) + 2-amino-3,5-dibromopyridine (35486-42-1) + ethyl acetate n-hexane + sodium carbonate (497-19-8) + phenylboronic acid (98-80-6) → 2-amino-3,5-diphenyl-pyridine (726138-31-4)

Guidance literature:

In methanol; water; toluene;

upstream raw materials:

2-amino-3,5-dibromopyridine

phenylboronic acid

bis-triphenylphosphine-palladium(II) chloride

sodium carbonate

Downstream raw materials:

2-iodo-3,5-diphenylpyridine

2-(4-bromo-phenyl)-6,8-diphenyl-imidazo[1,2-a]pyridine

[3-(3,5-diphenyl-pyridin-2-yl)-prop-2-ynyl]-dimethyl-amine

Refernces

• 1、 -. "Pyrene derivatives comprising heteroaryl amine group and organic light-emitting diode including the same". Paragraph 0337; 0392-0397. . Retrieved 2016/10/10.
• 2、 -. "AMIDE COMPOUND". Page/Page column 96. . Retrieved 2008/06/13.