52505-46-1

Basic information

• Product Name: ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE
• Synonyms: AKOS 94297;ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE;3-aminothieno[2,3-b]pyridine-2-carboxylic acid ethyl ester
• CAS NO: 52505-46-1
• Molecular Formula: C₁₀H₁₀N₂O₂S
• Molecular Weight: 222.26
• Product Categories: Heterocycles series;Esters;Fused Ring Systems;Building Blocks;Thieno[x,x-y]pyridine
• Mol File: 52505-46-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: 183 °C
• Boiling Point: 386.034 °C at 760 mmHg
• Flash Point: 187.267 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.675
• PKA: 4.96±0.40(Predicted)
• CAS DataBase Reference: ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE(52505-46-1)
• EPA Substance Registry System: ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE(52505-46-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 52505-46-1(Hazardous Substances Data)

Usage

General Description

ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE, also known as ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate, is a chemical compound with a molecular formula C11H9N3O2S. It is a type of pyridine derivative that contains a thieno ring and an ethyl ester group. ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE is a heterocyclic organic compound that has potential applications in the pharmaceutical industry. It may be used in the synthesis of pharmaceutical drugs or as a reference standard in chemical analysis. Its properties and potential uses make it an important compound in organic chemistry and drug development.

InChI:InChI=1/C10H10N2O2S/c1-2-14-10(13)8-7(11)6-4-3-5-12-9(6)15-8/h3-5H,2,11H2,1H3

Upstream product

• 20577-26-8 2-bromonicotinonitrile 
• 623-51-8 ethyl 2-sulfanylacetate 
• 52505-45-0 2-mercaptopyridine-3-carbonitrile 
• 105-39-5 chloroacetic acid ethyl ester 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 72832-23-6 ethyl 3-bromothieno(2,3-b)pyridine-2-carboxylate 
• 371944-56-8 2-phenylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one 
• 371943-98-5 C₁₅H₁₁N₃O₂S 
• 371943-39-4 C₁₅H₁₀N₂O₃S 
• 58327-75-6 3-aminothieno[2,3-b]pyridine-2-carboxylic acid 
• 59944-78-4 ethyl thieno[2,3-b]pyridine-2-carboxylate 
• 55115-79-2 Pyrido<3',2':4,5>thieno<3,2-d>pyrimidin-4(1H)-one 
• 58327-82-5 2-(4-chloro-benzylidene)-thieno[2,3-b]pyridin-3-one 
• 371943-54-3 C₁₇H₁₄N₂O₃S 
• 816424-66-5 lithium 3-[(2,4-difluorophenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate 
• 816464-46-7 tert-butyl 4-[({3-[(2,4-difluorophenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)amino]piperidine-1-carboxylate 
• 816464-41-2 tert-butyl (3R)-3-[({3-[(2,4-difluorophenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)amino]pyrrolidine-1-carboxylate 

Relevant articles and documents

GLUCOSE UPTAKE INHIBITORS AND USES THEREOF

The present invention relates to novel compounds that modulate cellular glucose uptake by affecting various targets, including, but not limited to those related to glycolysis and known transporters/co-transporters of the GLUT family. The compounds according to the invention are useful for treating cancer such as: neuroendrocrine neoplasms, gastrointestinal stromal tumors (GIST), renal cell carcinoma, paraganglioma, pheochromocytoma, pituitary adenoma, colorectal cancer, lung cancer, gastric cancer, pancreatic cancer sarcoma, head and neck cancer, melanoma, ovarian cancer and other cancers that rely on high levels of glycolysis for survival and proliferation; as well as in treating of autoimmune diseases, inflammation, infectious diseases, and metabolic diseases.

New annelated thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines, with potent anticancer activity, designed through VLAK protocol

Drug design was performed through the Virtual Lock-and-Key (VLAK) protocol. This in silico approach allowed to select new annelated thienotriazolopyrimidine derivatives, potentially antitumor drugs. Starting from benzothieno[2,3-e][1,2,3]triazolo[1,5-a]py

Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

Spiro-lactone (S)-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor and was found to be metabolically liable in human hepatic microsomes. To remove one of the risk factors in human study by improving the metabolic stability, we focused on modifying the