6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

Base Information

Chemical Name:6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole
CAS No.:72873-70-2
Molecular Formula:C17H15N3OS
Molecular Weight:309.392
Hs Code.:
ChEMBL ID:CHEMBL351053
DSSTox Substance ID:DTXSID30569256
Wikidata:Q82456369

Synonyms:72873-70-2;6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole;CHEMBL351053;SCHEMBL9343464;DTXSID30569256;ZHWNEMPWBUUIII-UHFFFAOYSA-N;6-(4-methoxyphenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]thiazole;6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole

Suppliers and Price of 6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:309.09358328
Heavy Atom Count:22
Complexity:369

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=C(N3CCSC3=N2)C4=CC=NC=C4

Technology Process of 6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

There total 5 articles about 6-(4-Methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 72873-70-2
6-(4-methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / benzyltrimethylammonium chloride / CH₂Cl₂; H₂O

2: 50 percent / KH / 2-methyl-propan-2-ol / 1.5 h / Ambient temperature

3: 68 percent / dimethylformamide / 4 h / Heating

4: 1.) NaH, 2.) K₂CO₃ / 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h

With benzyltrimethylammonium chloride; potassium hydride; sodium hydride; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00367a014

Reference yield:

: 87532-39-6
1-(4-methoxyphenyl)-2-hydroxy-2-(4-pyridyl)ethanone

: 72873-70-2
6-(4-methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / dimethylformamide / 4 h / Heating

2: 1.) NaH, 2.) K₂CO₃ / 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00367a014

Reference yield:

: 72873-67-7
1-(benzoyloxy)-1-(4-pyridyl)acetonitrile

: 72873-70-2
6-(4-methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / KH / 2-methyl-propan-2-ol / 1.5 h / Ambient temperature

2: 68 percent / dimethylformamide / 4 h / Heating

3: 1.) NaH, 2.) K₂CO₃ / 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h

With potassium hydride; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00367a014