4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione

Base Information

Chemical Name:4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione
CAS No.:72882-73-6
Molecular Formula:C₁₅H₁₃N₃OS
Molecular Weight:283.354
Hs Code.:
DSSTox Substance ID:DTXSID20606523
Wikidata:Q82505323

Synonyms:72882-73-6;SCHEMBL9340175;DTXSID20606523;CEHJBDNPWDCQRH-UHFFFAOYSA-N;4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione;4-(4-Methoxyphenyl)-5-(4-pyridyl)-2-mercaptoimidazole

Suppliers and Price of 4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:283.07793322
Heavy Atom Count:20
Complexity:396

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=C(NC(=S)N2)C3=CC=NC=C3

Technology Process of 4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione

There total 2 articles about 4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 72882-73-6
4-(4-methoxyphenyl)-5-(4-pyridyl)imidazole-2-thione

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / benzyltrimethylammonium chloride / CH₂Cl₂; H₂O

2: 50 percent / KH / 2-methyl-propan-2-ol / 1.5 h / Ambient temperature

3: 68 percent / dimethylformamide / 4 h / Heating

With benzyltrimethylammonium chloride; potassium hydride; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00367a014

Reference yield:

: 72873-67-7
1-(benzoyloxy)-1-(4-pyridyl)acetonitrile

: 72882-73-6
4-(4-methoxyphenyl)-5-(4-pyridyl)imidazole-2-thione

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / KH / 2-methyl-propan-2-ol / 1.5 h / Ambient temperature

2: 68 percent / dimethylformamide / 4 h / Heating

With potassium hydride; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00367a014

Reference yield:

: 72882-73-6
4-(4-methoxyphenyl)-5-(4-pyridyl)imidazole-2-thione

: 106-93-4
ethylene dibromide

: 72873-70-2
6-(4-methoxyphenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole

: 72873-71-3
5-(4-Methoxyphenyl)-6-(4-Pyridyl)-2,3-Dihydroimidazo[2,1-b]Thiazole

Guidance literature:: With sodium hydride; potassium carbonate; Multistep reaction; 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h;
DOI:10.1021/jm00367a014