3-phenylthiazolidine-2,4-dione

Base Information

• Chemical Name: 3-phenylthiazolidine-2,4-dione
• CAS No.: 1010-53-3
• Molecular Formula: C9H7 N O2 S
• Molecular Weight: 193.226
• Hs Code.: 2934999090
• Mol file: 1010-53-3.mol

Synonyms:2,4-Dioxo-3-phenyltetrahydro-1,3-thiazole;3-Phenyl-2,4-dioxothiazolidine; 3-Phenyl-2,4-thiazolidinedione;3-Phenylthiazolidine-2,4-dione; NSC 4745

Chemical Property of 3-phenylthiazolidine-2,4-dione

Chemical Property:

• Vapor Pressure: 0.000446mmHg at 25°C
• Boiling Point: 315.1°Cat760mmHg
• Flash Point: 144.4°C
• PSA: 62.68000
• Density: 1.416g/cm³
• LogP: 1.95140
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-PHENYL-2,4-THIAZOLIDINEDIONE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-phenylthiazolidine-2,4-dione

There total 78 articles about 3-phenylthiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

thiazoline-2,4-dione (2295-31-0) + diphenyliodonium tetrafluoroborate → 3-phenyl-2,4-thiazolidinedione (1010-53-3)

Guidance literature:

With potassium hydroxide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; at 80 ℃; for 2h;

DOI:10.3184/030823408X382144

Reference yield: 80.0%

1-phenyl-4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)thione (16325-43-2) + chloroacetic acid (79-11-8) → 3-phenyl-2,4-thiazolidinedione (1010-53-3)

Guidance literature:

In water; for 4h; Heating;

DOI:10.1016/S0040-4020(01)88577-X

Reference yield: 79.0%

Methyl thioglycolate (2365-48-2) + aniline (62-53-3) + 1,1'-carbonyldiimidazole (530-62-1) → 3-phenyl-2,4-thiazolidinedione (1010-53-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 72h;

DOI:10.1124/jpet.114.213777

upstream raw materials:

2-phenylaminothiazol-4-one

3-phenyl-2-(phenylimino)-1,3-thiazolidin-4-one

phenylcarbamimidoylmercapto-acetic acid

diethyl ether

Downstream raw materials:

5-(Z)-benzo[1,3]dioxol-5-ylmethylene-3-phenyl-thiazolidine-2,4-dione

3-phenyl-5-((Z)-piperonylidene)-thiazolidine-2,4-dione

5-(2-methyl-benzoimidazol-1-ylmethyl)-3-phenyl-thiazolidine-2,4-dione

5-[7-Oxo-7H-furo[3,4-b]pyrazin-(5Z)-ylidene]-3-phenyl-thiazolidine-2,4-dione

Refernces

• 1、 Markley,Reid. "-". . p. 2137,2140. Retrieved 1930.
• 2、 Ragab, Fatma Abd El-Fattah,Hassan, Ghaneya Sayed,Abu Yossef, Hanan Al-Sayed,Yahya, Tawfeek Ahmed Ali,Abd El-Latif, Hekma A.. "Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8- bromobenzopyran derivatives". . p. 171 - 176. Retrieved 2011/08/03.