Propanedioic acid, (2-chloro-4-nitrophenyl)-, dimethyl ester

Base Information

• Chemical Name: Propanedioic acid, (2-chloro-4-nitrophenyl)-, dimethyl ester
• CAS No.: 73088-10-5
• Molecular Formula: C11H10ClNO6
• Molecular Weight: 287.656

Synonyms:2-(2-Chloro-4-nitro-phenyl)-malonic acid dimethyl ester;2-(2-chloro-4-nitrophenyl)malonic acid dimethyl ester;dimethyl 2-(2-chloro-4-nitrophenyl)malonate;

Chemical Property of Propanedioic acid, (2-chloro-4-nitrophenyl)-, dimethyl ester

Chemical Property:

• Melting Point: 109 °C
• PSA: 98.42000
• LogP: 2.20100

Purity/Quality:

97% ^*data from raw suppliers

DIMETHYL2-(2-CHLORO-4-NITROPHENYL)MALONATE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanedioic acid, (2-chloro-4-nitrophenyl)-, dimethyl ester

There total 3 articles about Propanedioic acid, (2-chloro-4-nitrophenyl)-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3,4-dichloronitrobenzene (99-54-7) + malonic acid dimethyl ester (108-59-8) → 2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester (73088-10-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 70 ℃;

DOI:10.1016/S0040-4039(01)01809-3

Reference yield: 67.0%

3-chloro-4-fluoronitrobenzene (350-30-1) + malonic acid dimethyl ester (108-59-8) → 2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester (73088-10-5)

Guidance literature:

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 2h;

Reference yield:

→ 2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester (73088-10-5)

Guidance literature:

para-Nitrophenyltriflat (15), Malonsaeuredimethylester, NaH;

upstream raw materials:

3,4-dichloronitrobenzene

malonic acid dimethyl ester

3-chloro-4-fluoronitrobenzene

Downstream raw materials:

2-benzyl-2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester

2-allyl-2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester

2-(2-chloro-4-nitro-phenyl)-ethanol

[2-(2-chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-carbamic acid tert-butyl ester

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