MORPHOLIN-4-YL-(S)-PYRROLIDIN-2-YL-METHANONE

Base Information

• Chemical Name: MORPHOLIN-4-YL-(S)-PYRROLIDIN-2-YL-METHANONE
• CAS No.: 73094-26-5
• Molecular Formula: C9H16N2O2
• Molecular Weight: 184.23600
• Mol file: 73094-26-5.mol

Synonyms:H-Pro-morpholine;Butanoic acid,4-[(2-amino-1-oxo-3-phenylpropyl)amino]-3-hydroxy;

Chemical Property of MORPHOLIN-4-YL-(S)-PYRROLIDIN-2-YL-METHANONE

Chemical Property:

• Boiling Point: 356.8±42.0 °C(Predicted)
• PKA: 9.56±0.10(Predicted)
• PSA: 41.57000
• Density: 1.147±0.06 g/cm3(Predicted)
• LogP: -0.13610

Purity/Quality:

99% ^*data from raw suppliers

(S)-4-[(Pyrrolidin-2-yl)carbonyl]morpholineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MORPHOLIN-4-YL-(S)-PYRROLIDIN-2-YL-METHANONE

There total 5 articles about MORPHOLIN-4-YL-(S)-PYRROLIDIN-2-YL-METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-tert-butyl 2-(morpholine-4-carbonyl)pyrrolidine-1-carboxylate (537040-24-7) → morpholino(pyrrolidin-2-yl)methanone (73094-26-5,1096446-01-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2014.12.041

Reference yield:

(S)-4-morpholine (66165-42-2) → morpholino(pyrrolidin-2-yl)methanone (73094-26-5,1096446-01-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1246/bcsj.63.721

Reference yield:

N-Benzyloxycarbonyl-L-proline (1148-11-4) → morpholino(pyrrolidin-2-yl)methanone (73094-26-5,1096446-01-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / dimethylformamide / 0.25 h / -10 °C

2: dimethylformamide

3: H₂, AcOH / Pd / methanol

With hydrogen; acetic acid; triethylamine; palladium; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.40.3253

upstream raw materials:

(S)-4-morpholine

Cbz-L-Pro-OCO₂-i-Bu

N-Benzyloxycarbonyl-L-proline

1-(tert-butoxycarbonyl)-L-proline

Downstream raw materials:

(S)-4-[(2-pyrrolidinyl)methyl]morpholine

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