(S)-4-(pyrrolidin-2-ylmethyl)morpholine

Base Information

• Chemical Name: (S)-4-(pyrrolidin-2-ylmethyl)morpholine
• CAS No.: 91790-91-9
• Molecular Formula: C9H18N2O
• Molecular Weight: 170.25200
• Hs Code.: 2934999090
• European Community (EC) Number: 837-228-2
• DSSTox Substance ID: DTXSID90427989
• Nikkaji Number: J1.810.206D
• Wikidata: Q72505379
• Mol file: 91790-91-9.mol

Synonyms:91790-91-9;(S)-4-(pyrrolidin-2-ylmethyl)morpholine;(s)-4-(2-pyrrolidinylmethyl)morpholine;4-[[(2S)-pyrrolidin-2-yl]methyl]morpholine;4-[(2S)-2-Pyrrolidinylmethyl]morpholine;(S)-4-(2-Pyrrolidinylmethyl)morpholine dihydrochloride;4-{[(2S)-pyrrolidin-2-yl]methyl}morpholine;SCHEMBL1190922;DTXSID90427989;UUUSROHBEMVRKP-VIFPVBQESA-N;AMY24135;2alpha-(Morpholinomethyl)pyrrolidine;MFCD09723403;(s)-4-pyrrolidin-2-ylmethyl-morpholine;(S)-4-[(2-pyrrolidinyl)methyl]morpholine;CS-0372595;C78586;EN300-216603;(+)-(s)-2-[(morpholin-4-yl)methyl]pyrrolidine

Chemical Property of (S)-4-(pyrrolidin-2-ylmethyl)morpholine

Chemical Property:

• Boiling Point: 255oC
• Flash Point: 108oC
• PSA: 24.50000
• Density: 1.019
• LogP: 0.33730
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 170.141913202
• Heavy Atom Count: 12
• Complexity: 135

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-4-(2-Pyrrolidinylmethyl)morpholine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)CN2CCOCC2
• Isomeric SMILES: C1C[C@H](NC1)CN2CCOCC2

Technology Process of (S)-4-(pyrrolidin-2-ylmethyl)morpholine

There total 10 articles about (S)-4-(pyrrolidin-2-ylmethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-2-morpholin-4-ylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (380236-96-4) → (S)-4-[(2-pyrrolidinyl)methyl]morpholine (91790-91-9)

Guidance literature:

With HCl (g); In methanol;

Reference yield: 75.0%

(S)-N-(p-toluenesulphonyl)-2-(morpholinomethyl) pyrrolidine (114671-25-9) → (S)-4-[(2-pyrrolidinyl)methyl]morpholine (91790-91-9)

Guidance literature:

With lithium; In tetrahydrofuran; ethanol; ammonia; for 0.25h; Heating;

DOI:10.1016/S0040-4020(01)90297-2

Reference yield:

(S)-4-morpholine (66165-42-2) → (S)-4-[(2-pyrrolidinyl)methyl]morpholine (91790-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / methanol

2: LiAlH₄ / tetrahydrofuran / 20 h / Heating

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1246/bcsj.63.721

upstream raw materials:

morpholine

5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide

morpholino(pyrrolidin-2-yl)methanone

(S)-N-(p-toluenesulphonyl)-2-(morpholinomethyl) pyrrolidine