Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 73257-49-5
• Molecular Formula: C17H18ClNO4
• Molecular Weight: 335.787
• DSSTox Substance ID: DTXSID80352413
• Nikkaji Number: J509.696K
• ChEMBL ID: CHEMBL63260,CHEMBL2063641
• Mol file: 73257-49-5.mol

Synonyms:dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;73257-49-5;dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate;CBMicro_021521;3,5-dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;Oprea1_597989;Oprea1_824751;CHEMBL63260;CHEMBL2063641;SCHEMBL10895180;DTXSID80352413;HMS3428I07;CCG-8945;MFCD00619418;STK387364;AKOS000652975;3,5-Pyridinedicarboxylic acid,4-(4-chlorophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester;DS-10176;BIM-0021449.P001;CS-0101076;EU-0035148;AF-499/00049035;SR-01000403184;SR-01000403184-1;Z90339133;4-(4-Chloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester;dimethyl4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;5476-81-3

Chemical Property of Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

• PSA: 64.63000
• LogP: 3.24960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 335.0924357
• Heavy Atom Count: 23
• Complexity: 521

Purity/Quality:

97% ^*data from raw suppliers

Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=C(C=C2)Cl)C(=O)OC

Technology Process of Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 14 articles about Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetoacetic acid methyl ester (105-45-3) + para-Chlorobenzyl alcohol (873-76-7) → 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(4'-chlorophenyl)-1,4-dihydropyridine (73257-49-5)

Guidance literature:

With ammonium hydroxide; hydrogen bromide; dimethyl sulfoxide; In water; at 75 ℃; for 2.53333h;

DOI:10.1016/j.tetlet.2018.10.010

Reference yield: 96.0%

4-chlorobenzaldehyde (104-88-1) + acetoacetic acid methyl ester (105-45-3) → 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(4'-chlorophenyl)-1,4-dihydropyridine (73257-49-5)

Guidance literature:

With ammonium acetate; alginic acid; In ethanol; Reflux; Green chemistry;

DOI:10.1039/c4ra11801d

Reference yield: 96.0%

ammonium acetate (631-61-8,92206-38-7) + 4-chlorobenzaldehyde (104-88-1) + acetoacetic acid methyl ester (105-45-3) → 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(4'-chlorophenyl)-1,4-dihydropyridine (73257-49-5)

Guidance literature:

With iron supported on copper/Zeolite Socony Mobil-5 nanocatalyst; In water; at 20 ℃; Sonication;

DOI:10.1007/s13738-015-0734-5

upstream raw materials:

4-chlorobenzaldehyde

acetoacetic acid methyl ester

methyl (E)-3-aminocrotonate

4-methyleneoxetan-2-one

Downstream raw materials:

1,7-dioxo-8-(4'-chlorophenyl)-1,3,4,5,7,8-hexahydro(difuro)<3,4-b,3',4'-e>pyridine

dimethyl 4-(4-chlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

dimethyl 6-(4-chlorophenyl)-3,4-dimethyl-2,5-pyridinedicarboxylate

dimethyl 2-(4-chlorophenyl)-5,6-dimethyl-3,4-pyridinedicarboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 73257-49-5 Dimethyl 4-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send