2-{[(5-Nitrofuran-2-yl)methyl]amino}phenol

Base Information

• Chemical Name: 2-{[(5-Nitrofuran-2-yl)methyl]amino}phenol
• CAS No.: 73315-75-0
• Molecular Formula: C11H10N2O4
• Molecular Weight: 234.211
• DSSTox Substance ID: DTXSID60513949
• Wikidata: Q82373993

Synonyms:73315-75-0;2-{[(5-Nitrofuran-2-yl)methyl]amino}phenol;DTXSID60513949

Chemical Property of 2-{[(5-Nitrofuran-2-yl)methyl]amino}phenol

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 234.06405680
• Heavy Atom Count: 17
• Complexity: 269

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NCC2=CC=C(O2)[N+](=O)[O-])O

Technology Process of 2-{[(5-Nitrofuran-2-yl)methyl]amino}phenol

There total 5 articles about 2-{[(5-Nitrofuran-2-yl)methyl]amino}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-hydroxy-N-(5-nitrofurfurylidene)aniline (13060-78-1) → N-(2-hydroxyphenyl)-5-nitrofurfurylamine (73315-75-0)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; ethanol; at -35 ℃; for 1.5h;

DOI:10.1246/bcsj.56.1107

Reference yield: 42.7%

2-(bromomethyl)-5-nitrofuran (20782-91-6) + 2-amino-phenol (95-55-6) → N-(2-hydroxyphenyl)-5-nitrofurfurylamine (73315-75-0)

Guidance literature:

In N,N-dimethyl-formamide; for 1h; Ambient temperature;

Reference yield: 10.7%

2-(bromomethyl)-5-nitrofuran (20782-91-6) + 2-amino-phenol (95-55-6) → N-(2-hydroxyphenyl)-5-nitrofurfurylamine (73315-75-0) + 2-(5-Nitrofurfuryloxy)aniline (88796-65-0) + N,N'-bis(5-Nitrofurfuryl)-2-aminophenol (88796-68-3)

Guidance literature:

In pyridine; methanol; at 25 ℃; for 1.5h;

upstream raw materials:

2-hydroxy-N-(5-nitrofurfurylidene)aniline

2-(bromomethyl)-5-nitrofuran

2-amino-phenol

5-nitrofurane-2-carboxaldehyde

Downstream raw materials:

(E)-But-2-enoic acid (2-hydroxy-phenyl)-(5-nitro-furan-2-ylmethyl)-amide

Cyclohex-1-enecarboxylic acid (2-hydroxy-phenyl)-(5-nitro-furan-2-ylmethyl)-amide

C₁₈H₁₈N₂O₅

C₁₇H₁₆N₂O₅

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