Adenosine, 8-(4-fluorophenyl)-

Base Information

Chemical Name:Adenosine, 8-(4-fluorophenyl)-
CAS No.:73340-79-1
Molecular Formula:C16H16FN5O4
Molecular Weight:361.333
Hs Code.:
DSSTox Substance ID:DTXSID10447467

Synonyms:73340-79-1;(2R,3R,4S,5R)-2-(6-Amino-8-(4-fluorophenyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;Adenosine, 8-(4-fluorophenyl)-;DTXSID10447467;(2R,3R,4S,5R)-2-[6-amino-8-(4-fluorophenyl)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Suppliers and Price of Adenosine, 8-(4-fluorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Adenosine, 8-(4-fluorophenyl)-

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:361.11863217
Heavy Atom Count:26
Complexity:497

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC3=C(N=CN=C3N2C4C(C(C(O4)CO)O)O)N)F
Isomeric SMILES:C1=CC(=CC=C1C2=NC3=C(N=CN=C3N2[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N)F

Technology Process of Adenosine, 8-(4-fluorophenyl)-

There total 4 articles about Adenosine, 8-(4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

: 1765-93-1
4-fluoroboronic acid

: 2946-39-6
8-bromoadenosine

: 73340-79-1
8-(4-fluorophenyl)adenosine

Guidance literature:: With palladium diacetate; sodium carbonate; tris-(m-sulfonatophenyl)phosphine; In water; acetonitrile; at 80 ℃;
DOI:10.1021/jo034289p

Reference yield: 44.0%

: 352-34-1
4-fluoro-1-iodobenzene

: 58-61-7
adenosine

: 73340-79-1
8-(4-fluorophenyl)adenosine

Guidance literature:: With copper(l) iodide; caesium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 120 ℃; for 13h;
DOI:10.1016/j.tet.2008.01.062

Reference yield:

: 58-61-7
adenosine

: 73340-79-1
8-(4-fluorophenyl)adenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Br₂ / acetate buffer / 47 h / 20 °C / pH 4

2: 87 percent / aq. K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 16 h / 90 °C

With bromine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; acetate buffer; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1055/s-2004-831249