Phosphine, (4-chlorophenyl)diphenyl-

Base Information

• Chemical Name: Phosphine, (4-chlorophenyl)diphenyl-
• CAS No.: 734-60-1
• Molecular Formula: C18H14ClP
• Molecular Weight: 296.736
• DSSTox Substance ID: DTXSID00404201
• Nikkaji Number: J609.779K
• Mol file: 734-60-1.mol

Synonyms:Phosphine, (4-chlorophenyl)diphenyl-;734-60-1;(4-CHLOROPHENYL)DIPHENYLPHOSPHANE;(4-chlorophenyl)-diphenylphosphane;SCHEMBL8773581;DTXSID00404201

Chemical Property of Phosphine, (4-chlorophenyl)diphenyl-

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 3
• Exact Mass: 296.0521651
• Heavy Atom Count: 20
• Complexity: 255

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=C(C=C3)Cl

Technology Process of Phosphine, (4-chlorophenyl)diphenyl-

There total 31 articles about Phosphine, (4-chlorophenyl)diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-Chloro-4-iodobenzene (637-87-6) + (trimethylsilyl)diphenylphosphine (17154-34-6) → (4-chlorophenyl)diphenylphosphane (734-60-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In benzene; at 65 ℃; for 62h;

DOI:10.1021/jo00381a008

Reference yield: 89.0%

H3B(PPh2(C6H4Cl)) (1257322-31-8) → (4-chlorophenyl)diphenylphosphane (734-60-1)

Guidance literature:

In tetrahydrofuran; methanol; for 96h; Inert atmosphere; Molecular sieve; Reflux;

DOI:10.1016/j.jorganchem.2010.08.026

Reference yield: 88.0%

bromochlorobenzene (106-39-8) + (diphenylphosphino)(p-tolyl)methanone (40841-62-1) → (4-chlorophenyl)diphenylphosphane (734-60-1)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; In toluene; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.1c00937

upstream raw materials:

4-chlorophenyldichlorophosphine

bromochlorobenzene

chloro-diphenylphosphine

1-Chloro-4-iodobenzene

Downstream raw materials:

(4-chlorophenyl)diphenylphosphine sulfide

1-chloro-4-(diphenylphosphinoyl)benzene

Pd(SCN)2((ClC₆H₄)P(C₆H₅)2)2

p-chlorophenyldiphenylphosphanegold(I) chloride

Refernces

• 1、 Ye, Yun,Zhu, Jie,Huang, Yinhua. "Diverse C-P Cross-Couplings of Arylsulfonium Salts with Diarylphosphines via Selective C-S Bond Cleavage". supporting information. p. 2386 - 2391. Retrieved 2021/04/05.
• 2、 Fang, Zhiqiang,Cai, Mingzhong,Lin, Yang,Zhao, Hong. "An efficient heterogeneous cross-coupling of aryl iodides with diphenylphosphine catalyzed by copper (I) immobilized in MCM-41". . . Retrieved 2018/07/31.