4-Chloro-6-(4-fluorophenyl)-5-nitropyrimidine

Base Information

Chemical Name:4-Chloro-6-(4-fluorophenyl)-5-nitropyrimidine
CAS No.:736143-09-2
Molecular Formula:C10H5ClFN3O2
Molecular Weight:253.62
Hs Code.:
DSSTox Substance ID:DTXSID901252772

Synonyms:4-CHLORO-6-(4-FLUOROPHENYL)-5-NITROPYRIMIDINE;736143-09-2;SCHEMBL6662120;DTXSID901252772;AKOS014984945

Suppliers and Price of 4-Chloro-6-(4-fluorophenyl)-5-nitropyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-6-(4-fluorophenyl)-5-nitropyrimidine

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:253.0054323
Heavy Atom Count:17
Complexity:281

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=C(C(=NC=N2)Cl)[N+](=O)[O-])F

Technology Process of 4-Chloro-6-(4-fluorophenyl)-5-nitropyrimidine

There total 1 articles about 4-Chloro-6-(4-fluorophenyl)-5-nitropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4316-93-2
4,6-dichloro-5-nitropyrimidine

: 1765-93-1
4-fluoroboronic acid

: 736143-09-2
4-chloro-6-(4-fluorophenyl)-5-nitropyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 90 ℃;
DOI:10.1021/jm0408767

Reference yield: 95.0%

: 74-89-5
methylamine

: 736143-09-2
4-chloro-6-(4-fluorophenyl)-5-nitropyrimidine

: 736143-11-6
[6-(4-fluorophenyl)-5-nitropyrimidin-4-yl]methylamine

Guidance literature:: In 1,4-dioxane; water; for 1h; Heating;
DOI:10.1021/jm0408767

Reference yield:

: 736143-09-2
4-chloro-6-(4-fluorophenyl)-5-nitropyrimidine

: 6-(4-fluoro-phenyl)-9-methyl-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / dioxane; H₂O / 1 h / Heating

2: 90 percent / H₂ / Pd/C / CH₂Cl₂; ethanol / 0.5 h / 20 °C / 3000.24 Torr

3: 36 percent / p-toluenesulfonic acid / ethanol / Heating

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1021/jm0408767