2-(2-Chlorophenyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(2-Chlorophenyl)-1,3-dioxolane
• CAS No.: 7366-47-4
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• European Community (EC) Number: 665-824-0
• DSSTox Substance ID: DTXSID40398812
• Nikkaji Number: J1.072.022B
• Wikidata: Q82201006
• Mol file: 7366-47-4.mol

Synonyms:2-(2-chlorophenyl)-1,3-dioxolane;7366-47-4;2-chlorophenyl-[1,3]-dioxolan;SCHEMBL3214155;DTXSID40398812;GAZHHIWZNZPXQM-UHFFFAOYSA-N;AKOS006274024;2-CHLOROBENZALDEHYDE ETHYLENE KETAL

Chemical Property of 2-(2-Chlorophenyl)-1,3-dioxolane

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)C2=CC=CC=C2Cl

Technology Process of 2-(2-Chlorophenyl)-1,3-dioxolane

There total 3 articles about 2-(2-Chlorophenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-chloro-benzaldehyde (89-98-5) + ethylene glycol (107-21-1) → 2-(2'-chlorophenyl)-1,3-dioxolane (7366-47-4)

Guidance literature:

With poly(ethylene glycol) 1000 based dicationic acidic ionic liquid; In toluene; at 80 ℃; for 1h; Reagent/catalyst; Ionic liquid;

DOI:10.1016/j.molcata.2013.07.013

Reference yield: 87.0%

2-chloro-benzaldehyde (89-98-5) + 2-chloro-ethanol (107-07-3) → 2-(2'-chlorophenyl)-1,3-dioxolane (7366-47-4)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at -60 ℃; for 1.5h;

DOI:10.1021/ol0613113

Reference yield: 84.0%

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane (7381-30-8) + 2-chloro-benzaldehyde (89-98-5) → 2-(2'-chlorophenyl)-1,3-dioxolane (7366-47-4)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; at 20 ℃; for 4h;

DOI:10.1055/s-0030-1258148

upstream raw materials:

2-chloro-benzaldehyde

ethylene glycol

2-chloro-ethanol

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

Downstream raw materials:

C₁₄H₁₇ClO₃

C₁₆H₂₁ClO₃

2-phenyl-1,3-dioxolane

2-(2-propenyl)benzaldehyde ethylene glycol acetal

Refernces

• 1、 Belokon, Yuri N.,Gak, Alexander,Khakina, Ekaterina,Khrustalev, Victor N.,Korlyukov, Alexander A.,Kuznetsova, Svetlana,Li, Han,Lobanov, Nikolai,Nelyubina, Yulia,North, Michael,Peregudov, Alexander S.,Riazanov, Vladimir,Zhereb, Vladimir. "Inhibition by Water during Heterogeneous Br?nsted Acid Catalysis by Three-Dimensional Crystalline Organic Salts". . p. 6364 - 6372. Retrieved 2021/10/20.
• 2、 Zhou, Quan,Jia, Tao,Li, Xiao-Xuan,Zhou, Lin,Li, Chang-Jiang,Feng, Yi-Si. "House bulb light-induced photochemical acetalization of carbonyl compounds catalyzed by Eosin Y". supporting information. p. 1068 - 1075. Retrieved 2018/05/23.