BOC-LEU-ENKEPHALIN

Base Information

• Chemical Name: BOC-LEU-ENKEPHALIN
• CAS No.: 64963-27-5
• Molecular Formula: C33H45 N5 O9
• Molecular Weight: 655.748
• Mol file: 64963-27-5.mol

Synonyms:1-5-b-Neoendorphin (human),N-[(1,1-dimethylethoxy)carbonyl]- (9CI); L-Leucine,N-[N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl]glycyl]glycyl]-L-phenylalanyl]-;Boc-Leu-enkephalin

Chemical Property of BOC-LEU-ENKEPHALIN

Chemical Property:

• PSA: 212.26000
• LogP: 3.35790
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-LEU-ENKEPHALIN

There total 26 articles about BOC-LEU-ENKEPHALIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester (66831-30-9) → N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine (64963-27-5)

Guidance literature:

With hydrogen; palladium; In tert-butyl alcohol; for 16h;

DOI:10.1135/cccc19851329

Reference yield: 77.0%

5>-enkephalin (77511-32-1) → N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine (64963-27-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 0.333333h; Milling; Green chemistry;

DOI:10.1039/c3gc40302e

Reference yield:

Boc-Tyr-OH (3978-80-1) → N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine (64963-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) polystyrene-bound 1-hydroxybenzotriazole, dicyclohexylcarbodiimide (DCC) / 1.) CH₂Cl₂, RT, 6 h, 2.) CHCl₃, RT, 5 h

2: 1.) polystyrene-bound 1-hydroxybenzotriazole, dicyclohexylcarbodiimide (DCC) / 1.) CH₂Cl₂, RT, 6 h, 2.) CHCl₃, RT, 5 h

With HOBt-6-carboxamidomethyl polystyrene; dicyclohexyl-carbodiimide;

upstream raw materials:

tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine

Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester

5>-enkephalin

Boc-Tyr-Gly-Gly-Phe-Leu-OAce

Downstream raw materials:

Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester

tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester

Leu-enkephalin

Leu⁵-Eukephalin